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SHR Neuro Krebs Kardio Lipid

Mian, M; Wasle, I; Gamerith, G; Mondello, P; Melchardt, T; Jäger, T; Linkesch, W; Fiegl, M.
R-CHOP versus R-COMP: are they really equally effective?
Clin Oncol (R Coll Radiol). 2014; 26(10):648-652
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Linkesch Werner

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Plum Analytics:
The first-line standard treatment for diffuse large B-cell lymphoma (DLBCL) is the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). It is associated with cardiotoxicity, which is why new treatment strategies are needed. Liposomial doxorubicin has been proven to reduce these side-effects, but until now a direct comparison regarding efficacy has not yet been published. We retrospectively assessed 364 consecutive DLBCL patients who underwent either R-CHOP (218; 60%) or R-COMP (doxorubicin replaced by non-pegylated liposomal doxorubicin; 146; 40%) in first line and compared outcome and survival. We provide evidence that both regimens induce a high and comparable number of complete remissions and that both are able to cure patients with DLBCL. Confirmatory data are needed. Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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