Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Mian, M; Wasle, I; Gamerith, G; Mondello, P; Melchardt, T; Jäger, T; Linkesch, W; Fiegl, M.
R-CHOP versus R-COMP: are they really equally effective?
Clin Oncol (R Coll Radiol). 2014; 26(10):648-652
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Linkesch Werner
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
The first-line standard treatment for diffuse large B-cell lymphoma (DLBCL) is the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). It is associated with cardiotoxicity, which is why new treatment strategies are needed. Liposomial doxorubicin has been proven to reduce these side-effects, but until now a direct comparison regarding efficacy has not yet been published. We retrospectively assessed 364 consecutive DLBCL patients who underwent either R-CHOP (218; 60%) or R-COMP (doxorubicin replaced by non-pegylated liposomal doxorubicin; 146; 40%) in first line and compared outcome and survival. We provide evidence that both regimens induce a high and comparable number of complete remissions and that both are able to cure patients with DLBCL. Confirmatory data are needed. Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Antibodies, Monoclonal, Murine-Derived - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cyclophosphamide - therapeutic use
Doxorubicin - administration & dosage
Doxorubicin - analogs & derivatives
Doxorubicin - therapeutic use
Female -
Follow-Up Studies -
Humans -
Lymphoma, Large B-Cell, Diffuse - drug therapy
Lymphoma, Large B-Cell, Diffuse - mortality
Lymphoma, Large B-Cell, Diffuse - pathology
Male -
Middle Aged -
Neoplasm Staging -
Polyethylene Glycols - administration & dosage
Prednisone - therapeutic use
Prognosis -
Retrospective Studies -
Survival Rate -
Treatment Outcome -
Vincristine - therapeutic use
Young Adult -

Find related publications in this database (Keywords)
Diffuse large B-cell lymphoma
outcome
R-CHOP
R-COMP
© Meduni Graz Impressum