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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Valentin, A; Troppan, K; Pfeilstöcker, M; Nösslinger, T; Linkesch, W; Neumeister, P.
Safety and tolerability of intrathecal liposomal cytarabine as central nervous system prophylaxis in patients with acute lymphoblastic leukemia.
Leuk Lymphoma. 2014; 55(8):1739-1742
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Linkesch Werner
Neumeister Peter
Prochazka Katharina
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Abstract:
Central nervous system recurrence in acute lymphoblastic leukemia (ALL) occurs in up to 15% of patients and is frequently associated with poor outcome. The purpose of our study was to evaluate the efficacy and safety of a slow-release liposomal formulation of cytarabine for intrathecal (IT) meningeal prophylaxis in patients suffering from ALL. Forty patients aged 20-77 years (median 36) were preventively treated with a total of 96 (range 1-6) single doses containing 50 mg of liposomal cytarabine on a compassionate use basis. After a median observation period of 23 months (range 2-118) only two patients experienced a combined medullary-leptomeningeal disease recurrence after primary diagnosis. Except for headache grade 2 in two patients, no specific toxicity attributable to IT liposomal cytarabine application was noted. Long-term neurological side effects were not observed. IT liposomal cytarabine therapy with concomitant dexamethasone appears to be feasible and well tolerated.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Antimetabolites, Antineoplastic - administration & dosage
Antimetabolites, Antineoplastic - adverse effects
Central Nervous System Neoplasms - drug therapy
Central Nervous System Neoplasms - secondary
Cytarabine - administration & dosage
Cytarabine - adverse effects
Female -
Follow-Up Studies -
Humans -
Injections, Spinal -
Liposomes -
Male -
Middle Aged -
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Treatment Outcome -
Young Adult -

Find related publications in this database (Keywords)
Meningeosis
adverse events
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