Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Krause, R; Valentin, T; Salzer, H; Hönigl, M; Valentin, A; Auner, H; Zollner-Schwetz, I.
Which lumen is the source of catheter-related bloodstream infection in patients with multi-lumen central venous catheters?
Infection. 2013; 41(1):49-52
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Hönigl Martin
Krause Robert
Salzer Helmut J. F.
Valentin Thomas
Zollner-Schwetz Ines

Dimensions Citations:

Plum Analytics:
Purpose Paired blood cultures, drawn from the catheter and a peripheral vein, used for calculation of the differential time to positivity (DTP), have been proposed for the detection of catheter-related bloodstream infections (CRBSIs). The most relevant catheter lumen to be sampled in multi-lumen central venous catheters (CVCs) has not been recommended. Methods Forty-four febrile neutropaenic patients, following haematopoietic stem cell transplantation (HSCT) and with multi-lumen CVCs in place, were investigated using the DTP method of blood samples drawn from every lumen of the CVC and a peripheral vein. Results Twelve of 44 patients (27 %) had CRBSIs, as determined by the DTP method. In 10 of 12 (83 %) febrile neutropaenic patients, after HSCT, CRBSIs originated from the CVC lumen used for parenteral nutrition and blood products only. 17 % had CREST originating from the other CVC lumen (p = 0.039). Conclusion In most patients, CRBSIs originated from the CVC lumen used for parenteral nutrition and blood products, indicating that this lumen is the main source of CREST. However, since 17 % of patients had CRBSIs originating from another lumen, each lumen of multi-lumen CVCs has to be considered as a potential source of CREST and should, ideally, be sampled in order to avoid failure in diagnostic procedures.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Bacteremia - diagnosis
Catheter-Related Infections - diagnosis
Central Venous Catheters - adverse effects
Female -
Hematopoietic Stem Cell Transplantation -
Humans -
Male -
Middle Aged -
Neutropenia -

Find related publications in this database (Keywords)
Catheter-related bloodstream infection
Blood cultures
Stem cell transplantation
© Meduni Graz Impressum