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SHR Neuro Krebs Kardio Lipid

Unteregger, M; Valentin, A; Zinke-Cerwenka, W; Troppan, K; Deutsch, A; Cerroni, L; Linkesch, W; Neumeister, P.
Unrelated SCT induces long-term remission in patients with blastic plasmacytoid dendritic cell neoplasm.
Bone Marrow Transplant. 2013; 48(6):799-802 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo
Deutsch Alexander
Linkesch Werner
Neumeister Peter
Prochazka Katharina
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Abstract:
Blastic plasmacytoid DC neoplasm (BPDCN) is a rare haematopoietic malignancy with an aggressive behaviour. We evaluated five patients allografted as consolidative treatment with an unrelated donor in first or subsequent remission. Four patients received a reduced intensity-conditioning regimen because of age or co-morbidities. As the stem cell sources, two umbilical cord blood-(UCB), two PBSC- and one BM graft were used. No GVHD was observed in the patients who received a UCB graft. However, both developed a post-transplant-associated lymphoproliferative disease. So far, only one patient has experienced relapse and was consecutively treated by escalated donor lymphocyte infusions (DLI). A potent graft-versus-leukaemia (GVL) effect was induced leading to a 17-month-long CR. Four patients are still in ongoing CR with median disease-free and overall survivals of 17 and 21 months. Thus, allogeneic SCT in BPDCN offers a potential curative option for patients with a compatible donor. UCB is an attractive alternative as a stem cell source. For relapsing patients, DLI can exert a powerful GVL effect.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Disease-Free Survival -
Female -
Follow-Up Studies -
Graft vs Leukemia Effect -
Humans -
Lymphoproliferative Disorders - etiology
Male -
Middle Aged -
Neoplasms, Plasma Cell - mortality
Stem Cell Transplantation -
Survival Rate -
Time Factors -
Transplantation Conditioning -
Unrelated Donors -

Find related publications in this database (Keywords)
blastic plasmacytoid DC neoplasm
ASCT
umbilical cord blood transplantation
reduced intensity conditioning
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