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SHR Neuro Krebs Kardio Lipid

Schlick, K; Aigelsreiter, A; Pichler, M; Reitter, S; Neumeister, P; Hoefler, G; Beham-Schmid, C; Linkesch, W.
Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases.
Onkologie. 2012; 35(7-8):447-450 (- Case Report)
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Autor/innen der Med Uni Graz:
Aigelsreiter Ariane
Beham-Schmid Christine
Hoefler Gerald
Linkesch Werner
Neumeister Peter
Pichler Martin
Pichler Monika
Reitter Sonja
Schlick Konstantin
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Abstract:
Background: Histiocytic sarcoma (HS) is a rare but highly aggressive disease. The cancer-specific survival of patients with HS is short and only limited response to conventional chemotherapy or radiation therapy is seen. Some data from single case reports have suggested efficacy for high-dose chemotherapy and autologous/allogeneic stem cell transplantation. Case Report: We report on 4 cases of HS, and demonstrate that different druggable receptors are expressed on HS. Using immunohistochemistry, we detected the expression of platelet-derived growth factor receptor, vascular endothelial growth factor receptor and epidermal growth factor receptor, which are all well-known targets for novel targeted agents. Based on the marker profile, different novel targeted therapies including imatinib, sorafenib and bevacizumab were applied to the patients. We observed a varying clinical course for each patient. Conclusion: In our case series, we demonstrated that different receptors, which represent potential targets for novel drugs, are expressed on HS tumor cells. For a definitive assessment of the efficacy of these agents a prospective case study of a larger number of patients should be performed.
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Histiocytic Sarcoma - drug therapy
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Find related publications in this database (Keywords)
Histiocytic sarcoma
Immunohistochemistry
Tumor biology
Targeted therapy
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