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Fried, I; Bodner, C; Pichler, MM; Lind, K; Beham-Schmid, C; Quehenberger, F; Sperr, WR; Linkesch, W; Sill, H; Wölfler, A.
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia.
Haematologica. 2012; 97(2):246-250 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Beham-Schmid Christine
Bodner Claudia
Fried Isabella
Lind Karin
Linkesch Werner
Pichler Monika
Quehenberger Franz
Sill Heinz
Wölfler Albert
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Abstract:
The recent identification of DNMT3A mutations in de novo acute myeloid leukemia prompted us to determine their frequency, patterns and clinical impact in a cohort of 98 patients with either therapy-related or secondary acute myeloid leukemia developing from an antecedent hematologic disorder. We identified 24 somatic mutations in 23 patients with a significantly higher frequency in secondary acute myeloid leukemia (35.1%) as compared to therapy-related acute myeloid leukemia (16.4%, P=0.0486). DNMT3A mutations were associated with a normal karyotype and IDH1/2 mutations, but did not affect survival. In contrast to de novo acute myeloid leukemia, most mutations did not affect arginine on position 882, but were predominantly found in the methyltransferase domain. All DNMT3A mutations identified in secondary acute myeloid leukemia were already present in the antecedent disorders indicating an early event. Reduction to homozygosity by uniparental disomy was observed in 2 patients with secondary acute myeloid leukemia during disease progression.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Cohort Studies -
DNA (Cytosine-5-)-Methyltransferase - genetics
Female -
Humans -
Leukemia, Myeloid, Acute - epidemiology
Male -
Middle Aged -
Mutation - genetics
Neoplasms, Second Primary - epidemiology
Polymorphism, Single Nucleotide -
Tumor Markers, Biological - genetics

Find related publications in this database (Keywords)
acute myeloid leukemia
secondary and therapy-related AML
DNMT3A
mutation
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