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Zinke-Cerwenka, W; Valentin, A; Posch, U; Beham-Schmid, C; Groselj-Strele, A; Linkesch, W; Wölfler, A; Sill, H.
Reduced-intensity allografting in patients with therapy-related myeloid neoplasms and active primary malignancies.
Bone Marrow Transplant. 2011; 46(12):1540-1544 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Beham-Schmid Christine
Groselj-Strele Andrea
Linkesch Werner
Posch Ursula
Sill Heinz
Wölfler Albert
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Abstract:
Therapy-related myeloid neoplasms (t-MNs) are severe long-term consequences of cytotoxic treatments for a primary, often, malignant disorder. So far, the majority of patients eligible for transplantation have undergone myeloablative allo haematopoietic SCT (HSCT) as a potentially curative treatment, but it has been associated with high transplantation-related mortality (TRM) rates. In this retrospective study, we analysed the outcome of patients with t-MNs undergoing HSCT with reduced-intensity conditioning (RIC). Of 55 patients, seen at a single centre over a 10-year period, 17 underwent RIC HSCT with related or unrelated donors. The estimated overall survival was 53% at 1 year and 47% at 3 years, and disease-free survival was 47% at 1 year. At 1 year, the cumulative incidence of relapse and TRM were 24% and 30%, respectively. Of five patients with active primary neoplasms who underwent transplantation, two are alive beyond 1 year and show CR of both t-MNs and the primary malignancy. These data indicate that RIC HSCT is an encouraging approach for patients with t-MNs. The issue of primary malignancies not being in remission at the time of transplantation should be explored in further studies.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Disease-Free Survival -
Female -
Hematologic Neoplasms - mortality
Hematopoietic Stem Cell Transplantation -
Humans -
Male -
Middle Aged -
Retrospective Studies -
Survival Rate -
Time Factors -
Transplantation Conditioning -
Transplantation, Homologous -

Find related publications in this database (Keywords)
therapy-related myeloid neoplasms
reduced-intensity allografting
graft-vs-primary malignancy
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