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SHR Neuro Krebs Kardio Lipid

Wohlkoenig, C; Leithner, K; Deutsch, A; Hrzenjak, A; Olschewski, A; Olschewski, H.
Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells.
Cancer Lett. 2011; 308(2): 134-143.
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Autor/innen der Med Uni Graz:
Deutsch Alexander
Hrzenjak Andelko
Leithner Katharina
Olschewski Andrea
Olschewski Horst
Wohlkönig Christoph
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Abstract:
Hypoxia frequently occurs in solid tumors and is known to contribute to chemotherapy resistance. However, the mechanisms leading to chemotherapy resistance are not entirely known. We investigated hypoxia-induced resistance to cisplatin in NSCLC cell lines. We show that chronic moderate hypoxia induced resistance to cisplatin in NSCLC cells without involvement of selection pressure. Our data suggest that stabilization of the hypoxia-inducible factor 1 alpha and down-regulation of the pro-apoptotic protein BAX play a role in this process. Furthermore, we provide evidence that hypoxia-induced resistance to cisplatin is not due to the reduced growth rate of cancer cells under hypoxic conditions.
Find related publications in this database (using NLM MeSH Indexing)
Antineoplastic Agents - pharmacology
Apoptosis -
Blotting, Western -
Cell Hypoxia -
Cell Line, Tumor -
Cell Proliferation - drug effects
Cell Survival -
Cisplatin - pharmacology
Drug Resistance, Neoplasm -
Humans -
Lung Neoplasms - pathology
Reverse Transcriptase Polymerase Chain Reaction -

Find related publications in this database (Keywords)
Cisplatin
Apoptosis
Re-oxygenation
Growth rate
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