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SHR Neuro Krebs Kardio Lipid

Aigelsreiter, A; Gerlza, T; Deutsch, AJ; Leitner, E; Beham-Schmid, C; Beham, A; Popper, H; Borel, N; Pospischil, A; Raderer, M; Kessler, HH; Neumeister, P.
Chlamydia psittaci Infection in nongastrointestinal extranodal MALT lymphomas and their precursor lesions.
Am J Clin Pathol. 2011; 135(1): 70-75. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Aigelsreiter Ariane
Beham Alfred
Beham-Schmid Christine
Deutsch Alexander
Kessler Harald
Leitner-Meyer Eva
Neumeister Peter
Popper Helmuth
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Abstract:
Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence of Chlamydia psittaci, Chlamydia pneumoniae, and Chlamydia trachomatis DNA in 47 nongastrointestinal and 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, and 27 autoimmune precursor lesions by polymerase chain reaction amplification and direct sequencing. In 47 nongastrointestinal MALT lymphomas, 13 (28%) were positive for C psittaci DNA compared with 4 (11%) of 37 nonmalignant control samples (P = .09). C psittaci was detected at variable frequencies in MALT lymphomas of different sites: lung, 100% (5/5; P < .01); thyroid gland, 30% (3/10; P > .05); salivary gland, 13% (2/15; P > .05); ocular adnexa, 15% (2/13); and skin, 25% (1/4). Of 27 autoimmune precursor lesions (11 Hashimoto thyroiditis and 16 Sjögren syndrome), 11 (41%) contained C psittaci DNA. Only 1 (7%) of 14 gastrointestinal MALT lymphomas was positive for C psittaci. All specimens were negative for C trachomatis and C pneumoniae. Besides ocular adnexal lymphomas, C psittaci infection is associated with nongastrointestinal MALT lymphomas and autoimmune precursor lesions, suggesting possible involvement of C psittaci-induced antigenic-driven MALT lymphomagenesis.
Find related publications in this database (using NLM MeSH Indexing)
Antigens, Bacterial - analysis
Chlamydia trachomatis - genetics Chlamydia trachomatis - immunology Chlamydia trachomatis - isolation and purification
Chlamydophila pneumoniae - genetics Chlamydophila pneumoniae - immunology Chlamydophila pneumoniae - isolation and purification
Chlamydophila psittaci - genetics Chlamydophila psittaci - immunology Chlamydophila psittaci - isolation and purification
DNA, Bacterial - analysis
Eye Neoplasms - microbiology Eye Neoplasms - pathology
Hashimoto Disease - blood Hashimoto Disease - microbiology Hashimoto Disease - pathology
Humans -
Immunoenzyme Techniques -
Lymphoma, B-Cell, Marginal Zone - blood Lymphoma, B-Cell, Marginal Zone - microbiology Lymphoma, B-Cell, Marginal Zone - pathology
Psittacosis - blood Psittacosis - diagnosis Psittacosis - microbiology
Sequence Analysis, DNA -
Sjogren's Syndrome - blood Sjogren's Syndrome - microbiology Sjogren's Syndrome - pathology

Find related publications in this database (Keywords)
MALT lymphoma
Chlamydia psittaci
Infection
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