Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Schmidt, S; Wolf, D; Thaler, J; Burgstaller, S; Linkesch, W; Petzer, A; Fridrik, M; Lang, A; Agis, H; Valent, P; Krieger, O; Walder, A; Korger, M; Schlögl, E; Sliwa, T; Wöll, E; Mitterer, M; Eisterer, W; Pober, M; Gastl, G; on behalf of the ASHO CML registry.
First annual report of the Austrian CML registry.
Wien Klin Wochenschr. 2010; 122(19-20): 558-566.
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Linkesch Werner
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Abstract:
The Austrian chronic myeloid leukemia (CML) registry monitors individual disease courses, treatments applied, clinical outcome, and side effects of CML patients on a nationwide basis to provide data on the "real-life" situation and to complement the information and interpretation gained from the selected patient population observed in clinical trials. This report summarizes the Austrian CML registry data as of March 2009. A total of 179 patients have been registered with a median number of 1012 follow-up visits and median observation duration of 20 months. At diagnosis most patients (n = 163) were in chronic phase (early, late, and secondary), whereas only 4 were in advanced phase. A total of 137 patients were treated with tyrosine kinase inhibitors (TKIs), of which 14 received first and second generation TKIs sequentially. Other treatment modalities included chemotherapy or interferon and stem cell transplantation (SCT). Cumulative incidence rates for complete hematological responses (CHR) were 91.6% and 94.4% at 12 and 24 months, respectively, compared to cumulative incidence rates of complete cytogenetical response rates of 64% and 80% at these timepoints. A total of 5 patients progressed from chronic phase to accelerated (n = 3) and blastic phase (n = 2) while receiving imatinib standard dose. Estimated overall survival (OS) rate at 60 months was 90% and progression free survival (PFS) according to European Leukemia Net (ELN) failure definition was 58%.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Aged, 80 and over - epidemiology
Female -
Humans -
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis
Male -
Middle Aged -
Prevalence -
Registries - statistics and numerical data
Risk Assessment -
Risk Factors -
Survival Analysis -
Survival Rate -
Young Adult -

Find related publications in this database (Keywords)
CML
treatment
response
outcome
registry
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