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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Krones, E; Fickert, P; Zitta, S; Neunherz, S; Artinger, K; Reibnegger, G; Durchschein, F; Wagner, D; Stojakovic, T; Stadlbauer, V; Fauler, G; Stauber, R; Zollner, G; Kniepeiss, D; Rosenkranz, AR.
The chronic kidney disease epidemiology collaboration equation combining creatinine and cystatin C accurately assesses renal function in patients with cirrhosis.
BMC Nephrol. 2015; 16(4):196-196 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Artinger Katharina
Durchschein Franziska
Fauler Günter
Fickert Peter
Kniepeiss Daniela
Krones Elisabeth
Reibnegger Gilbert
Rosenkranz Alexander
Stadlbauer-Köllner Vanessa
Stauber Rudolf
Stojakovic Tatjana
Wagner Doris
Zitta Sabine
Zollner Gernot
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Number of Figures: 2
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Abstract:
Accurate measurement of renal function in cirrhotic patients is still challenging. To find the best test for the determination of the true glomerular filtration rate (GFR) in cirrhotic patients this study prospectively compared measured (m)GFR, the gold standard, with estimated (e)GFR using equations based on serum levels of creatinine and cystatin C. GFR was measured by sinistrin clearance using the bolus method in 50 patients with cirrhosis (Child Turcotte Pugh score A, B and C) and 24 age-matched healthy subjects as controls. Measured (m)GFR was compared to eGFR using bias, accuracy 10 % and 30 %, as well as correlation coefficients. Creatinine-based equations generally overestimated GFR in patients with cirrhosis and showed a bias (average difference between mGFR and eGFR) of -40 (CG), -12 (MDRD) and -9 (CKD-EPI-Cr) ml/min/1.73 m(2). Cystatin C-based equations underestimated GFR, especially in patients with Child Turcotte Pugh score C (bias 17 ml/min/1.73 m(2)for CKD-EPI-CysC). Of these equations, the CKD-EPI equation that combines creatinine and cystatin C (CKD-EPI-Cr-CysC) showed a bias of 0.12 ml/min/1.73 m(2) as compared to measured GFR. The CKD-EPI equation that combines serum creatinine and cystatin C measurements shows the best performance for accurate estimation of GFR in cirrhosis, especially at advanced stages.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged - epidemiology
Biomarkers -
Comorbidity -
Creatinine - blood
Cystatin C - blood
Diagnosis, Computer-Assisted - methods
Epidemiologic Research Design -
Female -
Glomerular Filtration Rate -
Humans -
Liver Cirrhosis - blood
Liver Cirrhosis - diagnosis
Liver Cirrhosis - epidemiology
Male -
Middle Aged -
Prevalence -
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Reproducibility of Results -
Risk Assessment - methods
Risk Factors -
Sensitivity and Specificity -
Young Adult -

Find related publications in this database (Keywords)
Cirrhosis
Cystatin C
Glomerular filtration rate
Renal function
Clearance
Sinistrin
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