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Thomas, J; Ohtsuka, M; Pichler, M; Ling, H.
MicroRNAs: Clinical Relevance in Colorectal Cancer.
Int J Mol Sci. 2015; 16(12):28063-28076 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Pichler Martin
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Abstract:
Colorectal cancer is one of the most common cancer diagnoses and causes of mortality worldwide. MicroRNAs are a class of small, non-coding regulatory RNAs that have shown strong associations with colorectal cancer. Through the repression of target messenger RNAs, microRNAs modulate many cellular pathways, such as those involved in cell proliferation, apoptosis, and differentiation. The utilization of microRNAs has shown significant promise in the diagnosis and prognosis of colorectal cancer, owing to their unique expression profile associations with cancer types and malignancies. Moreover, microRNA therapeutics with mimics or antagonists show great promise in preclinical studies, which encourages further development of their clinical use for colorectal cancer patients. The unique ability of microRNAs to affect multiple downstream pathways represents a novel approach for cancer therapy. Although still early in its development, we believe that microRNAs can be used in the near future as biomarkers and therapeutic targets for colorectal cancer.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Cell Transformation, Neoplastic - genetics
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Disease Progression -
Drug Resistance, Neoplasm - genetics
Gene Expression Regulation, Neoplastic -
Genes, Tumor Suppressor -
Genetic Association Studies -
Humans -
MicroRNAs - genetics
Molecular Targeted Therapy -
Oncogenes -
Prognosis -
Signal Transduction -

Find related publications in this database (Keywords)
colorectal cancer
miRNA
pathophysiology
diagnosis
prognosis
treatment
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