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SHR Neuro Krebs Kardio Lipid

Stadlbauer, V; Leber, B; Lemesch, S; Trajanoski, S; Bashir, M; Horvath, A; Tawdrous, M; Stojakovic, T; Fauler, G; Fickert, P; Högenauer, C; Klymiuk, I; Stiegler, P; Lamprecht, M; Pieber, TR; Tripolt, NJ; Sourij, H.
Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study.
PLoS One. 2015; 10(10):e0141399-e0141399 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Bashir Mina
Fauler Günter
Fickert Peter
Högenauer Christoph
Horvath Angela
Klymiuk Ingeborg
Leber Bettina
Lemesch Sandra
Pieber Thomas
Sourij Harald
Stadlbauer-Köllner Vanessa
Stiegler Philipp
Stojakovic Tatjana
Tawdrous Monika
Trajanoski Slave
Tripolt Norbert
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Abstract:
Metabolic syndrome is associated with disturbances in gut microbiota composition. We aimed to investigate the effect of Lactobacillus casei Shirota (LcS) on gut microbiota composition, gut barrier integrity, intestinal inflammation and serum bile acid profile in metabolic syndrome. In a single-centre, prospective, randomised controlled pilot study, 28 subjects with metabolic syndrome received either LcS for 12 weeks (n = 13) or no LcS (n = 15). Data were compared to healthy controls (n = 16). Gut microbiota composition was characterised from stool using 454 pyrosequencing of 16S rRNA genes. Serum bile acids were quantified by tandem mass spectrometry. Zonulin and calprotectin were measured in serum and stool by ELISA. Bacteroidetes/Firmicutes ratio was significantly higher in healthy controls compared to metabolic syndrome but was not influenced by LcS. LcS supplementation led to enrichment of Parabacteroides. Zonulin and calprotectin were increased in metabolic syndrome stool samples but not influenced by LcS supplementation. Serum bile acids were similar to controls and not influenced by LcS supplementation. Metabolic syndrome is associated with a higher Bacteroidetes/Firmicutes ratio and gut barrier dysfunction but LcS was not able to change this. LcS administration was associated with subtle microbiota changes at genus level. ClinicalTrials.gov NCT01182844.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Bile Acids and Salts - metabolism
Biodiversity -
Biomarkers -
Case-Control Studies -
Female -
Gastrointestinal Microbiome -
Humans -
Intestinal Mucosa - metabolism
Intestinal Mucosa - microbiology
Lactobacillus casei -
Male -
Metabolic Syndrome X - metabolism
Metabolic Syndrome X - microbiology
Middle Aged -
Pilot Projects -
Probiotics - administration & dosage

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