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Baranyi, A; Meinitzer, A; Breitenecker, RJ; Amouzadeh-Ghadikolai, O; Stauber, R; Rothenhäusler, HB.
Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis.
PLoS One. 2015; 10(9):e0137022-e0137022 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Baranyi Andreas
Meinitzer Andreas
Rothenhäusler Hans-Bernd
Stauber Rudolf
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Abstract:
The aim of this exploratory study is to gain for the first time a more comprehensive picture of the impact of changes of quinolinic acid concentrations on depressive symptomatology during and after IFN-α therapy. The quinolinic acid concentrations of 35 HCV patients are examined in a prospective survey over the entire period of IFN-α treatment as well as three months later at six different times (baseline, one, three, six and nine months after the beginning of IFN-α treatment, and after the end of treatment). During IFN-α treatment Hamilton Depression Rating Scale scores rise significantly. At the same time there is greater activity of indoleamine 2,3-dioxygenase, with a resulting increase in plasma kynurenine concentrations. Compared to baseline values quinolinic acid concentrations increase significantly during therapy, reflecting an increased neurotoxic challenge. In addition, patients with higher scores in the Hamilton Depression Rating Scale at six and nine months after starting therapy show significantly higher levels of quinolinic acid concentration. The increase of quinolinic acid during IFN-α therapy might contribute to depressive symptomatology through the neurotoxic challenge caused by quinolinic acid. Subsequently, our exploratory study results support the inflammatory hypothesis of depression. The awareness of relevant risk factors of IFN-α treatment-induced depression is essential to develop preventative treatment strategies.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Antiviral Agents - adverse effects
Depression - chemically induced
Female -
Hepatitis C, Chronic - drug therapy
Humans -
Interferon-alpha - adverse effects
Kynurenine - blood
Male -
Middle Aged -
Prospective Studies -
Psychiatric Status Rating Scales -
Quinolinic Acid - analysis

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