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SHR Neuro Krebs Kardio Lipid

Graninger, W.
Vasculitides Secondary to Infections
AKTUEL RHEUMATOL. 2015; 40(3): 223-226. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Graninger Winfried
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Abstract:
Chronic inflammation of the walls of blood vessels (vasculitis) is mediated by the host's immune system trying to eliminate the infectious element. This reaction can be perpetuated in a destructive manner after the presence of the infectious agent, in which case an immunosuppressive treatment is necessary to avoid damage incurred by the body's own defense system. However, detection of an infection in time can lead to a cure of the disease or at least to the termination of the erroneous reaction creating organ damage. Thus in all cases of newly proven vasculitis, "causative" or at least "associated" infections should be considered. This applies to all variants of the clinically so diverse forms of vasculitic diseases; there are notorious associations between Staphylococcus aureus and granulomatosis with polyangiitis or between polyangiitis nodosa and hepatitis B. Moreover, the perpetuation or reactivation of chronic systemic vasculitides by trivial infections deserves awareness and prophylactic strategies during immunomodulating therapies. Recent insights into the mechanisms of infection-related pathogenesis of vascular inflammatory disease could lead to better care and outcome in these rare diseases.

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