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Pasterk, L; Philipose, S; Eller, K; Marsche, G; Heinemann, A; Schuligoi, R.
The EP3 Agonist Sulprostone Enhances Platelet Adhesion But Not Thrombus Formation Under Flow Conditions.
Pharmacology. 2015; 96(3-4):137-143
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Autor/innen der Med Uni Graz:
Eller Kathrin
Heinemann Akos
Marsche Gunther
Pasterk Lisa
Philipose Sonia
Schuligoi Rufina
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Abstract:
Platelets express the EP2, EP3 and EP4 receptors. Prostaglandin (PG) E2 has a biphasic effect on platelets. Low concentrations of PGE2 enhance platelet aggregation through the activation of the EP3 receptors, while at high concentrations it attenuates aggregation via the EP4 receptor. Consequently, EP3 receptor inhibition was shown to inhibit artherothrombosis, but had no influence on bleeding time in vivo. In this study, we investigated the role of the EP3 receptor in adhesion and thrombus formation under flow conditions in vitro. The EP3 agonist sulprostone caused an increase in the adhesion of washed platelets to fibrinogen as well as to collagen under low shear stress, an effect that was blocked by the EP3 antagonist L-798106. In contrast, when whole blood was perfused over collagen-coated surfaces, sulprostone did not enhance binding and thrombus formation of platelets on collagen; at high concentrations it even attenuated this response. We conclude that in more physiological models of thrombus formation, the role for EP3 receptors is limited, indirectly suggesting that the primary action of PGE2 in haemostasis might be an inhibitory one. © 2015 S. Karger AG, Basel.
Find related publications in this database (using NLM MeSH Indexing)
Blood Platelets - drug effects
Blood Platelets - metabolism
Collagen - pharmacology
Dinoprostone - analogs & derivatives
Dinoprostone - pharmacology
Fibrinogen - pharmacology
Humans -
In Vitro Techniques -
Platelet Adhesiveness - drug effects
Platelet Aggregation - drug effects
Receptors, Prostaglandin E, EP3 Subtype - agonists
Sulfonamides - pharmacology
Thrombosis - blood
Thrombosis - chemically induced

Find related publications in this database (Keywords)
Platelet adhesion
Prostaglandin EP3 receptor
Thrombus formation under flow
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