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Lindenmann, J; Fink-Neuboeck, N; Schilcher, G; Smolle-Juettner, FM.
Severe methaemoglobinaemia treated with adjunctive hyperbaric oxygenation.
Diving Hyperb Med. 2015; 45(2):132-134 (- Case Report)
Web of Science PubMed

 

Autor/innen der Med Uni Graz:
Fink-Neuböck Nicole
Lindenmann Jörg
Schilcher Gernot
Smolle-Juettner Freyja-Maria
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Abstract:
Methaemoglobinaemia results from exposure to oxidizing substances such as nitrates or nitrites. Iron within haemoglobin is oxidized from the ferrous to the ferric state, which blocks the transport of oxygen and carbon dioxide, with subsequent inhibition of the respiratory chain. We describe the case of a 23-year-old male suffering from severe methaemoglobinaemia of 68% after consumption of nitrites ('poppers') in association with considerable ethanol consumption. Toluidine-blue was administered as first-line antidotal therapy immediately followed by hyperbaric oxygenation (HBOT). HBOT resulted in enhanced reduction of methaemoglobin, and rapid tissue re-oxygenation by the oxygen dissolved in plasma was provided, independent of the degree of methaemoglobinaemia. The patient recovered uneventfully and was discharged three days later. This case illustrates the potential of supportive HBOT as a time-saving therapeutic tool in this unusual situation, enabling a quick and sustained reduction in methaemoglobinaemia.
Find related publications in this database (using NLM MeSH Indexing)
Alcohol Drinking - adverse effects
Humans -
Hyperbaric Oxygenation - methods
Male -
Methemoglobinemia - blood
Methemoglobinemia - chemically induced
Methemoglobinemia - therapy
Nitrites - poisoning
Substance-Related Disorders - complications
Young Adult -

Find related publications in this database (Keywords)
Hyperbaric oxygen therapy
drugs
toxicity
hypoxia
neuroprotection
case reports
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