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SHR Neuro Krebs Kardio Lipid

Pichler, M; Calin, GA.
MicroRNAs in cancer: from developmental genes in worms to their clinical application in patients.
Br J Cancer. 2015; 113(4):569-573 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Pichler Martin
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Abstract:
Several discoveries have paved the way to personalise cancer medicine and a tremendous gain of knowledge in genomics and molecular mechanisms of cancer progression cumulated over the last years. Big stories in biology commonly start in a simple model system. No wonder microRNAs have been identified as regulators of embryonic development in the nematode Caenorhabditis elegans. From the first identification in worms to the first-in-man microRNA-based clinical trial in humans, almost 20 years passed. In this review we follow the story of understanding microRNA alterations in cancer, describe recent developments in the microRNA field and critically discuss their potential as diagnostic, prognostic and therapeutics factors in cancer medicine. We will explain the rationale behind the use of microRNAs in cancer diagnosis and prognosis prediction, but also discuss the limitations and pitfalls associated with this. Novel developments of combined microRNA/siRNA pharmacological approaches will be discussed and most recently data about MXR34, the first-tested microRNA drug will be described.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Embryonic Development - genetics
Genes, Developmental - genetics
Humans -
MicroRNAs - genetics
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - pathology
Prognosis -

Find related publications in this database (Keywords)
microRNAs
diagnosis
prognosis
treatment
worms
cancer
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