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SHR Neuro Krebs Kardio Lipid

Trauner, M; Halilbasic, E; Claudel, T; Steinacher, D; Fuchs, C; Moustafa, T; Pollheimer, M; Krones, E; Kienbacher, C; Traussnigg, S; Kazemi-Shirazi, L; Munda, P; Hofer, H; Fickert, P; Paumgartner, G.
Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.
Dig Dis. 2015; 33(3):433-439
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Claudel Thierry
Fickert Peter
Fuchs Claudia
Halilbasic Emina
Hofer Herwig
Krones Elisabeth
Moustafa Tarek
Pollheimer Marion
Trauner Michael
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Abstract:
24-nor-ursodeoxycholic acid (norUDCA) is a side-chain shortened derivate of ursodeoxycholic acid (UDCA). Since norUDCA is only ineffectively conjugated with glycine or taurine, it has specific physicochemical and therapeutic properties distinct from UDCA. Nonamidated norUDCA undergoes cholehepatic shunting enabling 'ductular targeting' and inducing a bicarbonate-rich hypercholeresis, with cholangioprotective effects. At the same time it has direct anti-inflammatory, antilipotoxic, anti fibrotic, and antiproliferative properties targeting various liver cell populations. norUDCA appears to be one of the most promising novel treatment approaches targeting the liver and the bile duct system at multifactorial and multicellular levels. This review article is a summary of a lecture given at the XXIII International Bile Acid Meeting (Falk Symposium 194) on 'Bile Acids as Signal Integrators and Metabolic Modulators' held in Freiburg, October 8-9, 2014, and summarizes the recent progress with norUDCA as a novel therapeutic approach in cholestatic and metabolic (liver) disorders. 2015 S. Karger AG, Basel.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Bile Duct Diseases - drug therapy
Humans -
Liver Diseases - drug therapy
Metabolic Diseases - drug therapy
Signal Transduction - drug effects
Ursodeoxycholic Acid - analogs & derivatives
Ursodeoxycholic Acid - therapeutic use

Find related publications in this database (Keywords)
Primary sclerosing cholangitis
Primary biliary cirrhosis
Bicarbonate umbrella
Nonalcoholic fatty liver disease
Atherosclerosis
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