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SHR Neuro Krebs Kardio Lipid

Zollner-Schwetz, I; Herzog, KA; Feierl, G; Leitner, E; Schneditz, G; Sprenger, H; Prattes, J; Petritsch, W; Wenzl, H; Kump, P; Gorkiewicz, G; Zechner, E; Högenauer, C.
The Toxin-Producing Pathobiont Klebsiella oxytoca Is Not Associated with Flares of Inflammatory Bowel Diseases.
Dig Dis Sci. 2015; 60(11):3393-3398
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Autor/innen der Med Uni Graz:
Feierl Gebhard
Gorkiewicz Gregor
Högenauer Christoph
Kump Patrizia
Leitner-Meyer Eva
Petritsch Wolfgang
Prattes Jürgen
Sprenger Hanna
Zollner-Schwetz Ines
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Abstract:
Alterations in the intestinal microbiota are thought to be involved in the pathogenesis of inflammatory bowel diseases (IBD). Klebsiella oxytoca is an intestinal pathobiont that can produce a cytotoxin (tillivaline). We aimed to elucidate the pathogenetic relevance of toxin-producing K. oxytoca in patients with IBD flares and investigated the clonal relationship of K. oxytoca isolates from IBD patients using multilocus sequence typing (MLST). Fecal samples of 235 adult IBD patients were collected from January 2008 to May 2009 and were tested for K. oxytoca, C. difficile toxin, and other pathogens by standard microbiological methods. Clinical data and disease activity scores were collected. K. oxytoca isolates were tested for toxin production using cell culture assays. A total of 45 K. oxytoca isolates from IBD patients, healthy, asymptomatic carriers and from patients with antibiotic-associated hemorrhagic colitis in part from our strain collection were tested for their clonal relationship using MLST. The prevalence of K. oxytoca in IBD overall was 4.7%. Eleven K. oxytoca isolates were detected. Two of 11 isolates were tested positive for toxin production. There was no significant difference in the distribution of K. oxytoca isolates between the groups (active vs. remission in UC and CD). MLST yielded 33 sequence types. K. oxytoca isolates from IBD did not cluster separately from isolates from asymptomatic carriers. Our data demonstrate that toxin (tilivalline)-producing K. oxytoca is not associated with IBD flares.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Bacterial Typing Techniques -
Benzodiazepinones - isolation & purification
Case-Control Studies -
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - microbiology
Crohn Disease - diagnosis
Crohn Disease - microbiology
DNA, Bacterial - genetics
Disease Progression -
Feces - microbiology
Female -
Humans -
Intestines - microbiology
Intestines - pathology
Klebsiella Infections - diagnosis
Klebsiella Infections - microbiology
Klebsiella oxytoca - classification
Klebsiella oxytoca - genetics
Klebsiella oxytoca - isolation & purification
Male -
Middle Aged -
Multilocus Sequence Typing -
Prospective Studies -
Risk Factors -
Young Adult -

Find related publications in this database (Keywords)
Klebsiella oxytoca
IBD
MLST
Toxin
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