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SHR Neuro Krebs Kardio Lipid

Hutterer, GC; Krieger, D; Mrsic, E; Pohlmann, K; Bezan, A; Stojakovic, T; Pummer, K; Zigeuner, R; Pichler, M.
Preoperative Leucocytosis, Thrombocytosis and Anemia as Potential Prognostic Factors in Non-metastatic Renal Cell Carcinoma.
Anticancer Res. 2015; 35(6):3463-3469
Web of Science PubMed

 

Autor/innen der Med Uni Graz:
Hutterer Georg C.
Pichler Martin
Pummer Karl
Stojakovic Tatjana
Terbuch Angelika
Zigeuner Richard
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Abstract:
To validate the potential prognostic significance of preoperatively assessed inflammatory parameters leucocytosis, thrombocytosis and anemia in patients with non-metastatic renal cell carcinoma (RCC). We retrospectively evaluated a cohort comprising 736 consecutive patients with non-metastatic RCC, operated on between 2004 and 2012 with curative radical or partial nephrectomy at a single tertiary academic centre. Laboratory parameters were assessed within one week before surgical intervention. Patients were categorized using laboratory parameter cut-off values according to receiver operating characteristics (ROC) analyses. Cancer-specific survival (CSS) was assessed using the Kaplan-Meier method. To evaluate the potential prognostic significance of the preoperative laboratory parameters, multivariate Cox regression models were applied. Multivariable analysis identified preoperative thrombocytosis (≥285,000/μl) as an independent prognostic factor for CSS (Hazard ratio=2.28, 95% confidence interval=1.24-4.20, p=0.008). Regarding CSS, an elevated preoperative platelet count represented an independent prognostic factor of poor survival. Our findings strengthen the potential prognostic significance of preoperative thrombocytosis in patients with non-metastatic RCC. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Anemia - complications
Anemia - diagnosis
Anemia - pathology
Carcinoma, Renal Cell - complications
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
Female -
Humans -
Kaplan-Meier Estimate -
Male -
Middle Aged -
Neoplasm Metastasis -
Nephrectomy -
Preoperative Period -
Prognosis -
Proportional Hazards Models -
Thrombocytosis - complications
Thrombocytosis - diagnosis
Thrombocytosis - pathology

Find related publications in this database (Keywords)
Anemia
leucocytosis
prognosis
renal cell carcinoma
thrombocytosis
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