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SHR Neuro Krebs Kardio Lipid

Zelzer, S; Mangge, H; Pailer, S; Ainoedhofer, H; Kieslinger, P; Stojakovic, T; Scharnagl, H; Prüller, F; Weghuber, D; Datz, C; Haybaeck, J; Obermayer-Pietsch, B; Trummer, C; Gostner, J; Gruber, HJ.
Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats.
Int J Mol Sci. 2015; 16(5):11689-11698 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Ainödhofer Herwig
Gruber Hans-Jürgen
Haybäck Johannes
Kieslinger Petra
Mangge Harald
Obermayer-Pietsch Barbara
Pailer Sabine
Prüller Florian
Scharnagl Hubert
Stojakovic Tatjana
Trummer Christian
Zelzer Sieglinde
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Abstract:
Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL), malondialdehyde (MDA), 4-hydroxynonenal (HNE), the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions were shown by T3 levels, both under normal and high fat diet. Thyroid dysfunctions were accompanied by changes in calorie intake and body weight as well as in the lipid profile. In detail, hypothyroid rats showed significantly decreased oxLDL levels, whereas hyperthyroid rats showed significantly increased oxLDL levels. These effects were seen under high fat diet and were less pronounced with normal feeding. Taken together, we showed for the first time in female SD rats that only hyper-, but not hypothyroidism, is associated with high atherogenic oxidized LDL irrespective of normal or high-fat diet in Sprague Dawley rats.
Find related publications in this database (using NLM MeSH Indexing)
Aldehydes - blood
Animals -
Body Weight -
Diet, High-Fat -
Female -
Hyperthyroidism - blood
Hypothyroidism - blood
Lipid Metabolism -
Lipids - blood
Lipoproteins, LDL - blood
Malondialdehyde - blood
Rats -
Rats, Sprague-Dawley -
Thyroid Gland - metabolism

Find related publications in this database (Keywords)
hyperthyroidism
oxidized LDL
hypothyroidism
fat feeding
metabolic dysfunction
Sprague Dawley rats
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