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SHR Neuro Krebs Kardio Lipid

Schaupp, L; Donsa, K; Neubauer, KM; Mader, JK; Aberer, F; Höll, B; Spat, S; Augustin, T; Beck, P; Pieber, TR; Plank, J.
Taking a Closer Look--Continuous Glucose Monitoring in Non-Critically Ill Hospitalized Patients with Type 2 Diabetes Mellitus Under Basal-Bolus Insulin Therapy.
Diabetes Technol Ther. 2015; 17(9):611-618
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Autor/innen der Med Uni Graz:
Aberer Felix
Höll Bernhard
Lichtenegger Katharina
Mader Julia
Pieber Thomas
Schaupp Lukas
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Abstract:
Inpatient glucose management is based on four daily capillary blood glucose (BG) measurements. The aim was to test the capability of continuous glucose monitoring (CGM) for assessing the clinical impact and safety of basal-bolus insulin therapy in non-critically ill hospitalized patients with type 2 diabetes mellitus (T2DM). Eighty-four patients with T2DM (age, 68±10 years; glycosylated hemoglobin, 72±28 mmol/mol; body mass index, 31±7 kg/m(2)) were treated with basal-bolus insulin. CGM was performed with the iPro(®)2 system (Medtronic MiniMed, Northridge, CA) and calibrated retrospectively. A remarkable consistency between CGM and BG measurements and therapy improvement was shown over the study period of 501 patient-days. The number of CGM and BG measurements (CGM/BG) in the range from 3.9-10 mmol/L increased from 67.7%/67.2% (on Day 1) to 77.5%/78.6% (on the last day) (P<0.04). The number of low glycemic episodes (3.3 to <3.9 mmol/L) during nighttime detected by CGM was 15-fold higher, and the number of episodes >13.9 mmol/L detected by CGM during night was 12.5-fold higher than the values from the BG measurements. Ninety-nine percent of data points were in the clinically accurate or acceptable Clarke Error Grid Zones A+B, and the relative numbers of correctly identified episodes of <3.9 and >13.9 mmol/L detected by CGM (sensitivity) were 47.3% and 81.5%, respectively. Our data exhibit a good agreement between overall CGM and BG measurements, but there were a high number of missed hypo- and hyperglycemic episodes with BG measurements, particularly during nighttime. Overall assessment of glycemic control using CGM is feasible, whereas the use of CGM for individualized therapy decisions needs further improvement.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Algorithms -
Blood Glucose - analysis
Blood Glucose Self-Monitoring - instrumentation
Blood Glucose Self-Monitoring - methods
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Female -
Glycated Hemoglobin A - analysis
Hospitalization -
Humans -
Hypoglycemia - chemically induced
Hypoglycemic Agents - administration & dosage
Insulin - administration & dosage
Male -
Middle Aged -
Reproducibility of Results -

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