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Pieber, TR; Deller, S; Korsatko, S; Jensen, L; Christiansen, E; Madsen, J; Heller, SR.
Counter-regulatory hormone responses to hypoglycaemia in people with type 1 diabetes after 4 weeks of treatment with liraglutide adjunct to insulin: a randomized, placebo-controlled, double-blind, crossover trial.
Diabetes Obes Metab. 2015; 17(8):742-750
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Autor/innen der Med Uni Graz:
Deller Sigrid
Korsatko Stefan
Pieber Thomas
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Abstract:
To investigate the effect of glucagon-like peptide 1 receptor agonist liraglutide on the counter-regulatory hormone response to hypoglycaemia in type 1 diabetes. We conducted a randomized, double-blind, placebo-controlled, single-centre trial, in which a total of 45 adults with type 1 diabetes [mean ± standard deviation age 34.5 ± 11.2 years, BMI 23.9 ± 2.4 kg/m(2) , glycated haemoglobin (HbA1c) 7.6 ± 0.8%, diabetes duration 16.6 ± 9.4 years] underwent a hypoglycaemic clamp after 4 weeks' crossover treatment with once-daily liraglutide/placebo added to insulin in one of three liraglutide dose groups: 0.6 mg (n = 15); 1.2 mg (n = 14); and 1.8 mg (n = 16). The main outcome measure was glucagon concentration at nadir plasma glucose (2.5 mmol/l). Clinical outcomes were also evaluated. Five participants were withdrawn from the trial; three because of adverse events. All participants were included in the analysis. Glucagon concentration at nadir plasma glucose was modest, trending towards lower concentrations at increasing liraglutide dose versus placebo: 34.7 versus 38.1 pg/ml, p = 0.555 (0.6 mg); 28.8 versus 37.2 pg/ml, p = 0.126 (1.2 mg); and 28.4 versus 37.5 pg/ml, p = 0.092 (1.8 mg). There was no difference, however, between liraglutide and placebo in incremental change in glucagon during hypoglycaemia. Other counter-regulatory hormone levels increased during hypoglycaemia with no systematic differences between groups. Glucose infusion rates were significantly lower with liraglutide versus placebo during the clamp. After 4 weeks' treatment, HbA1c remained unchanged in the liraglutide and placebo groups. Greater reductions in insulin dose and body weight were seen with liraglutide versus placebo. Liraglutide did not compromise hypoglycaemic responses in type 1 diabetes after 4 weeks' treatment. © 2015 John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Body Weight -
Cross-Over Studies -
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Double-Blind Method -
Drug Therapy, Combination - methods
Female -
Glucagon - metabolism
Glucagon-Like Peptide 1 - therapeutic use
Glucose - administration & dosage
Glucose Clamp Technique -
Glycated Hemoglobin A - drug effects
Glycated Hemoglobin A - metabolism
Humans -
Hypoglycemia - drug therapy
Hypoglycemia - metabolism
Hypoglycemic Agents - therapeutic use
Insulin - therapeutic use
Liraglutide - therapeutic use
Male -
Middle Aged -

Find related publications in this database (Keywords)
catecholamines
counter-regulation
GLP-1
glucagon
glucose infusion rate
hypoglycaemia
hypoglycaemic clamp
incretin therapy
liraglutide
type 1 diabetes
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