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SHR Neuro Krebs Kardio Lipid

Dalpiaz, O; Pichler, M; Mrsic, E; Reitz, D; Krieger, D; Venturino, L; Bezan, A; Stojakovic, T; Pummer, K; Zigeuner, R; Hutterer, GC.
Preoperative serum-gamma-glutamyltransferase (GGT) does not represent an independent prognostic factor in a European cohort of patients with non-metastatic renal cell carcinoma.
J Clin Pathol. 2015; 68(7):547-551
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Autor/innen der Med Uni Graz:
Dalpiaz Orietta
Hutterer Georg C.
Pichler Martin
Pummer Karl
Stojakovic Tatjana
Terbuch Angelika
Zigeuner Richard
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Abstract:
Increasing evidence suggests that the serum-gamma-glutamyltransferase (GGT) might correlate with tumour development and growth rates in various human cancer types. Thus, we decided to investigate the potential prognostic impact of the preoperatively assessed serum-GGT in a European cohort of patients with non-metastatic renal cell carcinoma (RCC). Clinicopathological data from 700 consecutive patients with non-metastatic RCC, operated between 2000 and 2010 at a single tertiary academic centre, were evaluated retrospectively. Preoperative serum-GGT was assessed 1 day before surgery. Patients were categorised using a serum-GGT cut-off value of 40 U/L according to a calculation by receiver operating curve analysis. Patients' cancer-specific survival (CSS), metastasis-free survival (MFS), as well as overall survival (OS) were assessed using the Kaplan-Meier method and Cox proportional models. In univariate analysis, an elevated preoperative serum-GGT level (<40 U/L vs ≥40 U/L) was statistically significantly associated with a shorter MFS (HR=1.517, 95% CI 1.047 to 2.197, p=0.027). In multivariate analyses, pathological T-Stage (pT-1 vs pT-2-4, HR=2.065, 95% CI 1.665 to 2.560), tumour grade (G-1+G-2 vs G-3+G-4, HR=1.671, 95% CI 1.261 to 2.213), as well as the presence of histological tumour necrosis (No vs Yes, HR=2.031, 95% CI 1.355 to 3.046) were independent predictors of MFS in patients with RCC, whereas the preoperative serum-GGT failed to reach independent predictor status (<40 U/L vs ≥40 U/L, HR=1.156, 95% CI 0.791 to 1.690). No prognostic role for GGT in OS or CSS could be identified. In the cohort studied, patients with an elevated (≥40 U/L) preoperative serum-GGT had a subsequently shorter MFS only in univariate analysis. In contrast to previous studies, our data failed to demonstrate preoperatively assessed serum-GGT as an independent prognostic factor in patients with non-metastatic RCC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Area Under Curve -
Area Under Curve - epidemiology
Biomarkers, Tumor - blood
Carcinoma, Renal Cell - blood
Carcinoma, Renal Cell - enzymology
Carcinoma, Renal Cell - ethnology
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
Disease-Free Survival -
European Continental Ancestry Group -
Female -
Humans -
Kaplan-Meier Estimate -
Kidney Neoplasms - blood
Kidney Neoplasms - enzymology
Kidney Neoplasms - ethnology
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Male -
Multivariate Analysis -
Necrosis -
Neoplasm Grading -
Neoplasm Staging -
Predictive Value of Tests -
Proportional Hazards Models -
ROC Curve -
Retrospective Studies -
Risk Factors -
Time Factors -
Up-Regulation -
gamma-Glutamyltransferase - blood

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