Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Troppan, K; Hofer, S; Wenzl, K; Lassnig, M; Pursche, B; Steinbauer, E; Wiltgen, M; Zulus, B; Renner, W; Beham-Schmid, C; Deutsch, A; Neumeister, P.
Frequent down regulation of the tumor suppressor gene a20 in multiple myeloma.
PLoS One. 2015; 10(4):e0123922-e0123922 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Beham-Schmid Christine
Deutsch Alexander
Hofer Sybille
Neumeister Peter
Prochazka Katharina
Renner Wilfried
Steinbauer Elisabeth
Wenzl Kerstin
Wiltgen Marco
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Abstract:
Multiple myeloma (MM) is a malignant clonal expansion of plasma cells in the bone marrow and belongs to the mature B-cell neoplams. The pathogenesis of MM is associated with constitutive NF-κB activation. However, genetic alterations causing constitutive NF-κB activation are still incompletely understood. Since A20 (TNFAIP3) is a suppressor of the NF-κB pathway and is frequently inactivated in various lymphoid malignancies, we investigated the genetic and epigenetic properties of A20 in MM. In total, of 46 patient specimens analyzed, 3 single base pair exchanges, 2 synonymous mutations and one missense mutation were detected by direct sequencing. Gene copy number analysis revealed a reduced A20 gene copy number in 8 of 45 (17.7%) patients. Furthermore, immunohistochemical staining confirmed that A20 expression correlates with the reduction of A20 gene copy number. These data suggest that A20 contributes to tumor formation in a significant fraction of myeloma patients.
Find related publications in this database (using NLM MeSH Indexing)
Apoptosis - genetics
Carcinogenesis - genetics
DNA-Binding Proteins - biosynthesis
Gene Dosage - genetics
Gene Expression Regulation, Neoplastic -
Humans -
Intracellular Signaling Peptides and Proteins - biosynthesis
Multiple Myeloma - genetics
Mutation, Missense -
NF-kappa B - genetics
Nuclear Proteins - biosynthesis
Tumor Suppressor Proteins - biosynthesis

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