Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Ljubojevic, S; Bers, DM.
Nuclear calcium in cardiac myocytes.
J Cardiovasc Pharmacol. 2015; 65(3):211-217 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Holzer Senka
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Abstract:
Calcium (Ca) is a universal second messenger involved in the regulation of various cellular processes, including electrical signaling, contraction, secretion, memory, gene transcription, and cell death. In heart, Ca governs cardiomyocyte contraction, is central in electrophysiological properties, and controls major signaling pathway implicated in gene transcription. How cardiomyocytes decode Ca signal to regulate gene expression without interfering with, or being controlled by, "contractile" Ca that floods the entire cytosol during each heartbeat is still elusive. In this review, we summarize recent findings on nuclear Ca regulation and its downstream signaling in cardiomyocytes. We will address difficulties in reliable quantification of nuclear Ca fluxes and discuss its role in the development and progression of cardiac hypertrophy and heart failure. We also point out key open questions to stimulate future work.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Calcium - metabolism
Calcium Signaling -
Cardiomegaly - metabolism
Cardiomegaly - physiopathology
Cell Nucleus - metabolism
Heart Failure - metabolism
Heart Failure - physiopathology
Humans -
Myocytes, Cardiac - metabolism
Receptors, Cell Surface - metabolism
Receptors, Cytoplasmic and Nuclear - metabolism

Find related publications in this database (Keywords)
nuclear calcium
cardiomyocyte
calcium signaling
cardiac remodeling
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