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Hutterer, GC; Sobolev, N; Ehrlich, GC; Gutschi, T; Stojakovic, T; Mannweiler, S; Pummer, K; Zigeuner, R; Pichler, M; Dalpiaz, O.
Pretreatment lymphocyte-monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma.
J Clin Pathol. 2015; 68(5):351-355
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Autor/innen der Med Uni Graz:
Dalpiaz Orietta
Ehrlich Georg
Gutschi Thomas
Hutterer Georg C.
Mannweiler Sebastian
Pichler Martin
Pummer Karl
Stojakovic Tatjana
Zigeuner Richard
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Abstract:
To investigate the potential prognostic impact of the lymphocyte-monocyte ratio (LMR) in a large European cohort of patients with localised upper urinary tract urothelial carcinoma (UTUC). The LMR as an indicator of systemic inflammatory response has been shown to represent a potential prognostic factor in various types of human cancers. Up to date, the prognostic significance of the LMR in UTUC has not been evaluated. Clinico-pathological data from 182 non-metastatic patients with UTUC, operated between 1990 and 2012 at a single tertiary academic centre, were evaluated retrospectively. Pretreatment LMR was assessed 1 day before surgery. Patients were categorised using an LMR cut-off value of 2.0 according to a calculation by receiver-operating curve analysis. Patients' overall survival (OS) was assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the LMR, a multivariate proportional Cox regression model was applied for OS. In multivariate analyses, age on the date of surgery (<65 vs ≥65 years, HR=2.10, 95% CI 1.22 to 3.64), pathological T-stage (pT1 vs pT2-4, HR=2.15, 95% CI 1.26 to 3.67), as well as the LMR (<2 vs ≥2, HR=0.56, 95% CI 0.35 to 0.92) were independent predictors of OS of patients with UTUC. In the cohort studied, patients with an elevated (≥2) preoperative LMR had a subsequently longer OS after radical surgery for UTUC, compared with those with a low (<2) preoperative LMR. Thus, we believe this parameter might be considered an additional prognostic factor in UTUC in the future. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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Adult -
Age Factors -
Aged -
Aged, 80 and over -
Area Under Curve -
Area Under Curve -
Carcinoma - blood
Carcinoma - pathology
Carcinoma - therapy
Chi-Square Distribution -
Female -
Humans -
Kaplan-Meier Estimate -
Lymphocyte Count -
Lymphocytes -
Male -
Middle Aged -
Monocytes -
Multivariate Analysis -
Neoplasm Staging -
Predictive Value of Tests -
Proportional Hazards Models -
ROC Curve -
Retrospective Studies -
Risk Factors -
Time Factors -
Treatment Outcome -
Urologic Neoplasms - blood
Urologic Neoplasms - mortality
Urologic Neoplasms - pathology
Urologic Neoplasms - therapy
Urothelium - pathology

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