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SHR Neuro Krebs Kardio Lipid

Stelzer, I; Kröpfl, JM; Fuchs, R; Pekovits, K; Mangge, H; Raggam, RB; Gruber, HJ; Prüller, F; Hofmann, P; Truschnig-Wilders, M; Obermayer-Pietsch, B; Haushofer, AC; Kessler, HH; Mächler, P.
Ultra-endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function.
Scand J Med Sci Sports. 2015; 25(5):e442-e450
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Autor/innen der Med Uni Graz:
Fuchs Robert
Gruber Hans-Jürgen
Haushofer Alexander C.
Kessler Harald
Kröpfl Julia
Mangge Harald
Obermayer-Pietsch Barbara
Pekovits Karin
Prüller Florian
Raggam Reinhard Bernd
Stelzer Ingeborg
Truschnig-Wilders Martini
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Abstract:
Although amateur sports have become increasingly competitive within recent decades, there are as yet few studies on the possible health risks for athletes. This study aims to determine the impact of ultra-endurance exercise-induced stress on the number and function of circulating hematopoietic progenitor cells (CPCs) and hematological, inflammatory, clinical, metabolic, and stress parameters in moderately trained amateur athletes. Following ultra-endurance exercise, there were significant increases in leukocytes, platelets, interleukin-6, fibrinogen, tissue enzymes, blood lactate, serum cortisol, and matrix metalloproteinase-9. Ultra-endurance exercise did not influence the number of CPCs but resulted in a highly significant decline of CPC functionality after the competition. Furthermore, Epstein-Barr virus was seen to be reactivated in one of seven athletes. The link between exercise-induced stress and decline of CPC functionality is supported by a negative correlation between cortisol and CPC function. We conclude that ultra-endurance exercise induces metabolic stress and an inflammatory response that affects not only mature hematopoietic cells but also the function of the immature hematopoietic stem and progenitor cell fraction, which make up the immune system and provide for regeneration. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Colony-Forming Units Assay -
Female -
Fibrinogen - metabolism
Hematopoietic Stem Cells - physiology
Herpesvirus 4, Human - physiology
Humans -
Hydrocortisone - blood
Inflammation - blood
Inflammation - etiology
Interleukin-6 - blood
Lactic Acid - blood
Leukocyte Count -
Male -
Matrix Metalloproteinase 9 - blood
Middle Aged -
Physical Conditioning, Human - adverse effects
Physical Endurance -
Platelet Count -
Stress, Physiological - physiology
Virus Activation -

Find related publications in this database (Keywords)
Circulating hematopoietic stem and progenitor cells
functionality
ultra-endurance exercise
stress
inflammation
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