Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Münzker, J; Hofer, D; Trummer, C; Ulbing, M; Harger, A; Pieber, T; Owen, L; Keevil, B; Brabant, G; Lerchbaum, E; Obermayer-Pietsch, B.
Testosterone to dihydrotestosterone ratio as a new biomarker for an adverse metabolic phenotype in the polycystic ovary syndrome.
J Clin Endocrinol Metab. 2015; 100(2):653-660 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Harger Alexandra
Lerchbaum Elisabeth
Münzker Julia
Obermayer-Pietsch Barbara
Pieber Thomas
Sudy Daniela
Trummer Christian
Ulbing Matthias
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
Polycystic ovary syndrome (PCOS) is a heterogeneous disease with many different aspects, including hyperandrogenism and metabolic disturbances. Clinical phenotypes show different patterns of steroid hormones that have been investigated to some extent. This study intended to determine the role of the testosterone (TT) to dihydrotestosterone (DHT) ratio (TT/DHT ratio) in PCOS patients and to further assess the correlation of this ratio with hormonal, anthropometric, and metabolic parameters. Serum samples of 275 premenopausal PCOS patients fulfilling Rotterdam criteria and 35 BMI-matched, premenopausal, healthy controls were analyzed for testosterone, DHT, dehydroepiandrosterone (DHEA), and androstenedione using liquid chromatography/mass spectrometry. We measured total levels of testosterone and DHT and calculated unbound hormone levels as well as the ratio of testosterone to DHT. Further, impaired glucose tolerance, basal and stimulated serum insulin levels, metabolic syndrome and insulin resistance according to the homeostatic model assessment (HOMA-IR) were assessed. PCOS patients showed significantly higher levels of TT (P < .001), free testosterone (P < .001), and free DHT (P < .001) compared to healthy controls. The TT/DHT ratio was significantly higher in PCOS patients (P < .001). No difference was found for total DHT levels (P = .072). In PCOS patients alone, the TT/DHT ratio was significantly higher in obese patients (P < .001) and patients with metabolic syndrome (P < .001), impaired glucose tolerance (IGT) (P < .001) or insulin resistance (P < .001). Significant correlations of the TT/DHT ratio with various adverse anthropometric, hormonal, lipid and liver parameters and parameters of glucose metabolism were found. Our data provide evidence for a strong link between a high TT/DHT ratio and an adverse metabolic phenotype in PCOS patients. This correlation was only found in PCOS patients, suggesting the TT/DHT ratio to be a new biomarker for an adverse metabolic phenotype in PCOS patients.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Biomarkers - blood
Dihydrotestosterone - blood
Female -
Glucose Intolerance - blood
Glucose Intolerance - complications
Glucose Intolerance - diagnosis
Humans -
Insulin - blood
Insulin Resistance - physiology
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - diagnosis
Middle Aged -
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Testosterone - blood
Young Adult -

© Meduni Graz Impressum