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SHR Neuro Krebs Kardio Lipid

Belaj, K; Hackl, G; Rief, P; Eller, P; Brodmann, M; Gary, T.
Changes in lipid metabolism and extension of venous thromboembolism.
Ann Nutr Metab. 2014; 64(2):122-126
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Autor/innen der Med Uni Graz:
Belaj Klara
Brodmann Marianne
Eller Philipp
Gary Thomas
Hackl Gerald
Rief Peter
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Abstract:
Deep vein thrombosis (DVT) and pulmonary embolism (PE) are common diseases with a vast number of acquired and congenital risk factors. Disorders of the lipid metabolism are not established risk factors for venous thromboembolism (VTE) so far. However, in recent literature, associations between VTE and the metabolic syndrome, especially with elevated lipid parameters, have been described. The aim of our study was to investigate the association between the extension of VTE and changes in the lipid profile. We included 178 VTE patients in our study; 59 patients had isolated PE, 39 patients had isolated DVT of the leg and 80 patients had both (DVT and PE). Concerning PE, we distinguished between massive and submassive PE. We evaluated plasma lipids and lipoproteins in PE and DVT patients as well as in massive and submassive PE patients. PE patients had higher levels of plasma triglycerides [median (interquartile range): 162 (109-254) vs. 136.5 (96.5-162) mg/dl, p = 0.047] and lower levels of high-density lipoprotein cholesterol (HDL-C; 52.1 ± 17.2 vs. 63.9 ± 22.7 mg/dl, p = 0.004) than DVT patients. Furthermore, PE patients were significantly older than DVT patients (59.6 ± 16.9 vs. 52.2 ± 15.5 years, p = 0.02). We were not able to find differences in lipid parameters in patients with massive PE compared to those with submassive PE. However, patients with massive PE were more obese than patients with submassive PE (body mass index 29.1 ± 4.6 vs. 26.9 ± 4.9, p = 0.012). Lipid parameters and lipoproteins differ between DVT and PE patients. PE patients had higher triglyceride and lower HDL-C levels compared with DVT patients. © 2014 S. Karger AG, Basel.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Body Mass Index -
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Female -
Humans -
Lipid Metabolism - physiology
Logistic Models -
Male -
Middle Aged -
Pulmonary Embolism - blood Pulmonary Embolism - physiopathology
Retrospective Studies -
Risk Factors -
Triglycerides - blood
Venous Thromboembolism - blood Venous Thromboembolism - physiopathology
Venous Thrombosis - blood Venous Thrombosis - physiopathology

Find related publications in this database (Keywords)
Deep vein thrombosis
Pulmonary embolism
Venous thromboembolism
Lipids
Lipoproteins
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