Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Absenger, G; Benhaim, L; Szkandera, J; Zhang, W; Yang, D; Labonte, MJ; Pichler, M; Stotz, M; Samonigg, H; Renner, W; Gerger, A; Lenz, HJ.
The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy.
Pharmacogenomics J. 2014; 14(2):130-134
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Autor/innen der Med Uni Graz:
Absenger Gudrun
Gerger Armin
Pichler Martin
Renner Wilfried
Samonigg Hellmut
Stotz Michael
Szkandera Joanna
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Abstract:
Recent evidence indicates a potential prognostic and predictive value for germline polymorphisms in genes involved in cell cycle control. We investigated the effect of cyclin D1 (CCND1) rs9344 G>A in stage II/III colon cancer patients and validated the findings in an independent study cohort. For evaluation and validation set, a total of 264 and 234 patients were included. Patients treated with 5-fluorouracil-based chemotherapy, carrying the CCND1 rs9344 A/A genotype had significantly decreased time-to-tumor recurrence (TTR) in univariate analysis and multivariate analysis (hazard ratio (HR) 2.47; 95% confidence interval (CI) 1.16-5.29; P=0.019). There was no significant association between CCND1 rs9344 G>A and TTR in patients with curative surgery alone. In the validation set, the A allele of CCND1 rs9344 G>A remained significantly associated with decreased TTR in univariate and multivariate analyses (HR 1.94; 95% CI 1.05-3.58; P=0.035). CCND1 rs9344 G>A may be a predictive and/or prognostic biomarker in stage II/III colon cancer patients, however, prospective trials are warranted to confirm our findings.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Alleles -
Chemotherapy, Adjuvant - adverse effects
Colonic Neoplasms - drug therapy
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
Cyclin D1 - genetics
Female -
Fluorouracil - administration & dosage
Fluorouracil - adverse effects
Humans -
Male -
Middle Aged -
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - genetics
Polymorphism, Single Nucleotide -
Prognosis -
Treatment Outcome -

Find related publications in this database (Keywords)
biomarker
CCND1
chemotherapy
colon cancer
polymorphism
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