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SHR Neuro Krebs Kardio Lipid

Cavalieri, M; Enzinger, C; Petrovic, K; Pluta-Fuerst, A; Homayoon, N; Schmidt, H; Fazekas, F; Schmidt, R.
Vascular dementia and Alzheimer's disease - are we in a dead-end road?
Neurodegener Dis. 2010; 7(1-3): 122-126.
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Autor/innen der Med Uni Graz:
Cavalieri Margherita
Enzinger Christian
Fazekas Franz
Homayoon Nina
Petrovic Katja Elisabeth
Pluta-Fürst Aga
Schmidt Helena
Schmidt Reinhold
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Abstract:
Background: Diagnostic criteria separating vascular dementia from other dementias, particularly Alzheimer's disease (AD) neglect the real world in which most AD cases present with at least some vascular brain lesions. Most importantly, vascular lesions, even if subtle, exert significant effects on the patients' cognitive functioning if they coexist with AD pathology. Objectives: To emphasize the need for an integrative dementia concept in which the vascular component represents an important end point in trial planning and a possibility for disease modification along the whole spectrum of combined vascular and primary degenerative pathology. Methods: Review of the literature on possible surrogate markers to study the contribution of vascular brain damage in dementia. Results: The longitudinal change in volume of white matter lesions is the best elaborated putative surrogate marker for the study of the vascular component in dementia. Validation of the role of lacunes and microbleeds as surrogate end points is poor. Loss of brain volume is an important adjunct outcome measure even though the vascular origin of atrophy remains uncertain. Conclusions: A focus on pure vascular dementia distracts from the importance of vascular factors in dementia. Consideration of the vascular component in future clinical trials will improve our pathophysiological understanding and provide options for treatment. Copyright (C) 2010 S. Karger AG, Basel
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Alzheimer Disease - complications Alzheimer Disease - epidemiology
Cognition Disorders - etiology
Dementia, Vascular - complications Dementia, Vascular - diagnosis Dementia, Vascular - epidemiology
Female -
Humans -

Find related publications in this database (Keywords)
Vascular dementia
Brain imaging
Diagnostic criteria
Surrogate marker
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