Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Malli, R; Graier, WF.
Mitochondrial Ca2+ channels: Great unknowns with important functions.
FEBS Lett. 2010; 584(10): 1942-1947. [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG Google Scholar

 

Autor/innen der Med Uni Graz:
Graier Wolfgang
Malli Roland
Altmetrics:

Dimensions Citations:

Plum Analytics:
Number of Figures: 1
|
Abstract:
Mitochondria process local and global Ca(2+) signals. Thereby the spatiotemporal patterns of mitochondrial Ca(2+) signals determine whether the metabolism of these organelles is adjusted or cell death is executed. Mitochondrial Ca(2+) channels of the inner mitochondrial membrane (IMM) actually implement mitochondrial uptake from cytosolic Ca(2+) rises. Despite great efforts in the past, the identity of mitochondrial Ca(2+) channels is still elusive. Numerous studies aimed to characterize mitochondrial Ca(2+) uniport channels and provided a detailed profile of these great unknowns with important functions. This mini-review revisits previous research on the mechanisms of mitochondrial Ca(2+) uptake and aligns them with most recent findings.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Biological Transport -
Calcium - metabolism
Calcium Channels - chemistry
Humans -
Mitochondria - metabolism
Phosphorylation -

Find related publications in this database (Keywords)
Calcium signaling
ER Ca2+ release
grp75
IP3 receptor
Letm1
mCa1
mCa2
MiCa
MCU
Mitochondrial Ca2+ uniporter
Mitofusin
p38MAPK
Uncoupling protein
UCP2/3
© Meduni Graz Impressum