Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Marsche, G; Frank, S; Hrzenjak, A; Holzer, M; Dirnberger, S; Wadsack, C; Scharnagl, H; Stojakovic, T; Heinemann, A; Oettl, K.
Plasma-advanced oxidation protein products are potent high-density lipoprotein receptor antagonists in vivo.
Circ Res. 2009; 104(6): 750-757. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Frank Saša
Heinemann Akos
Holzer Michael
Hrzenjak Andelko
Marsche Gunther
Öttl Karl
Scharnagl Hubert
Stojakovic Tatjana
Wadsack Christian

Dimensions Citations:

Plum Analytics:
Number of Figures: 5
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Advanced oxidation protein products (AOPPs) are carried by oxidized plasma proteins, especially albumin and accumulate in subjects with renal disease and coronary artery disease. AOPPs represent an excellent novel marker of oxidative stress and their roles in the development of cardiovascular disease might be of great importance. Here, we show that in vitro-generated AOPP-albumin binds with high affinity to the high-density lipoprotein (HDL) receptor scavenger receptor class B type I (SR-BI). Already an equimolar concentration of AOPP-albumin to HDL blocked HDL association to SR-BI and effectively inhibited SR-BI-mediated cholesterol ester (CE) uptake. Interestingly, albumin extensively modified by advanced glycation end products (AGE-albumin), which is an established SR-BI ligand known to accumulate in renal disease, only weakly interfered with HDL binding to SR-BI. Furthermore, AOPP-albumin administration increased the plasma half-life of [3H]CE-HDL in control mice 1.6-fold (P=0.01) and 8-fold (P=0.0003) in mice infected with adenoviral vectors encoding human SR-BI. Moreover, albumin isolated from hemodialysis patients, but not albumin isolated from healthy controls, markedly inhibited SR-BI-mediated HDL-CE transfer in vitro dependent on the AOPP content of albumin. These results indicate that AOPP-albumin effectively blocks SR-BI in vitro and in vivo. Thus, depressed plasma clearance of HDL-cholesterol may contribute to the abnormal composition of HDL and the high cardiovascular risk observed in patients with chronic renal failure.
Find related publications in this database (using NLM MeSH Indexing)
Albumins - chemistry
Animals -
CHO Cells -
Cardiovascular Diseases - etiology
Cholesterol, HDL - genetics
Cricetinae -
Cricetulus -
Half-Life -
Humans -
Kidney Failure, Chronic - complications
Mice -
Oxidation-Reduction -
Protein Binding - genetics
Protein Carbonylation -
Risk Factors -
Scavenger Receptors, Class B - antagonists and inhibitors

Find related publications in this database (Keywords)
oxidative stress
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