Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Riederer, M; Erwa, W; Zimmermann, R; Frank, S; Zechner, R.
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.
Atherosclerosis. 2009; 204(2):412-417
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Erwa Wolfgang
Frank Saša
Riederer Monika
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
Nicotinamide N-methyltransferase (NNMT) catalyses the conversion of nicotinamide to 1-methylnicotinamide and plays an important role in hepatic detoxification reactions. Here we show that, in addition to the liver, 3T3-L1 adipocytes as well as human and murine adipose tissue explants express high amounts of enzymatically active NNMT. NNMT mRNA levels and enzyme activity increased in 3T3-L1 cells in a differentiation-dependent manner. Homocysteine, the atherogenic product of the NNMT-catalyzed reaction, was secreted from 3T3-L1 cells or adipose tissue cultures. Homocysteine release increased during 3T3-L1 differentiation and was reduced when adipose tissue was treated with the NNMT inhibitor 1-methylnicotinamide. Nicotinic acid (NA), a widely used drug to lower elevated plasma lipid levels, induced NNMT enzyme activity in white adipose tissue of mice. In tissue culture nicotinamide treatment led to an increase in adipose tissue homocysteine secretion. These data support the concept that adipose tissue NNMT contributes to the increased plasma homocysteine levels in patients treated with NA.
Find related publications in this database (using NLM MeSH Indexing)
3T3-L1 Cells -
Adipocytes - drug effects Adipocytes - enzymology
Adipogenesis -
Adipose Tissue - drug effects Adipose Tissue - enzymology
Animals -
Enzyme Inhibitors - pharmacology
Female -
Gene Expression Regulation, Enzymologic -
Homocysteine - metabolism
Humans -
Hypolipidemic Agents - pharmacology
Male -
Mice -
Mice, Inbred C57BL -
Niacin - pharmacology
Niacinamide - analogs & derivatives Niacinamide - pharmacology
Nicotinamide N-Methyltransferase - antagonists & inhibitors Nicotinamide N-Methyltransferase - genetics Nicotinamide N-Methyltransferase - metabolism
RNA, Messenger - metabolism
Time Factors -

Find related publications in this database (Keywords)
NNMT
Nicotinamide
Methyltransferase
Adipose tissue
Homocysteine
Nicotinic acid
Atherosclerosis
© Meduni Graz Impressum