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SHR Neuro Krebs Kardio Lipid

Calayir, E; Becker, TM; Kratzer, A; Ebner, B; Panzenböck, U; Stefujl, J; Kostner, GM.
LXR-agonists regulate ApoM expression differentially in liver and intestine.
Curr Pharm Biotechnol. 2008; 9(6): 516-521.
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Autor/innen der Med Uni Graz:
Becker Tatjana
Gallé Birgit
Kostner Gerhard
Kratzer Adelheid
Panzenboeck Ute
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Abstract:
Apolipoprotein M (apoM) has been suggested to play a role in reverse cholesterol transport. Here we studied the influence of liver X-receptor (LXR) agonist on the transcriptional regulation of apoM. Studies were performed in murine liver and intestinal mucosal cells in vivo and in human intestinal Caco-2 cells in vitro. The expression of apoM was analyzed by quantitative real time PCR, and compared to well-established LXR target genes. Mice fed with TO901317 for six days showed a downregulation of apoM and apoAI in the liver to 40 % and 60 % respectively and an upregulation of Cyp7A1 to 280 %. In the small intestine, however, apoM and apoAI were upregulated by 30-60 % and ABCA1 by 250-430 %. In Caco-2 cells TO901317 caused a 60 % upregulation and the natural LXR agonist 22-hydroxycholesterol a 40 % upregulation of apoM. Possible causes for the differential effects in liver and intestine are discussed.
Find related publications in this database (using NLM MeSH Indexing)
Apolipoproteins - metabolism
Caco-2 Cells -
DNA-Binding Proteins - drug effects DNA-Binding Proteins - metabolism
Gene Expression Regulation - drug effects Gene Expression Regulation - physiology
Humans -
Hydrocarbons, Fluorinated - administration and dosage
Intestines - drug effects Intestines - metabolism
Liver - drug effects Liver - metabolism
Organ Specificity - drug effects Organ Specificity - physiology
Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - metabolism
Signal Transduction - drug effects Signal Transduction - physiology
Sulfonamides - administration and dosage

Find related publications in this database (Keywords)
Intestine
lipid metabolism
lipocalin
expression profiling
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