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SHR Neuro Krebs Kardio Lipid

Sovic, A; Balazs, Z; Hrzenjak, A; Reicher, H; Panzenboeck, U; Malle, E; Sattler, W.
Scavenger receptor class B, type I mediates uptake of lipoprotein-associated phosphatidylcholine by primary porcine cerebrovascular endothelial cells.
NEUROSCI LETT. 2004; 368(1): 11-14.
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Autor/innen der Med Uni Graz:
Hrzenjak Andelko
Malle Ernst
Panzenboeck Ute
Reicher Helga
Sattler Wolfgang
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Abstract:
We previously reported that scavenger receptor class B, type I (SR-BI) mediates uptake of lipoprotein-associated cholesteryl ester and Vitamin E by porcine brain capillary endothelial cells (pBCECs). In the present study we investigated whether SR-BI is capable of mediating phosphatidylcholine (PC) uptake by pBCECs from low- and high density lipoproteins. SR-BI-overexpressing CHO cells and pBCECs showed significantly enhanced uptake rates of PC from both lipoprotein classes. In addition, preincubation of pBCECs in the presence of both lipoprotein species resulted in a significant increase of the cellular fatty acid content, particularly linoleic and arachidonic acid. Our results suggest that uptake of lipoprotein-associated PC by the cerebrovasculature via SR-BI could generate a pool of lipids containing polyunsaturated fatty acids available for transport into deeper regions of the brain.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Antigens, CD36 -
CHO Cells -
Capillaries - cytology
Cerebrovascular Circulation - physiology
Cricetinae - physiology
Culture Media, Serum-Free - physiology
Endothelial Cells - metabolism
Fatty Acids, Unsaturated - metabolism
Humans - metabolism
Lipoproteins - metabolism
Lipoproteins, HDL - metabolism
Lipoproteins, LDL - metabolism
Phosphatidylcholines - metabolism
Receptors, Immunologic - physiology
Receptors, Scavenger - physiology
Scavenger Receptors, Class B - physiology
Swine - physiology

Find related publications in this database (Keywords)
SR-BI
phospholipids
HDL
LDL
brain endothelial cells
selective lipid uptake
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