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SHR Neuro Krebs Kardio Lipid

Enzinger, C; Ropele, S; Smith, S; Strasser-Fuchs, S; Poltrum, B; Schmidt, H; Matthews, PM; Fazekas, F.
Accelerated evolution of brain atrophy and black holes in MS patients with APOE-epsilon 4.
ANN NEUROL. 2004; 55: 563-569.
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Enzinger Christian
Fazekas Franz
Fuchs Siegrid
Poltrum Birgit
Ropele Stefan
Schmidt Helena
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Abstract:
Apolipoprotein E (APOE)-epsilon4 has been associated with an unfavorable course of multiple sclerosis (MS). The mechanisms responsible for this are unclear, although cross-sectional MRI demonstrated a higher extent of "black holes" (BHs) in such patients. Here, we have studied the impact of the APOE genotype on both the longitudinal evolution of focal (BH ratio) and global (brain volume change [BVC]) brain tissue damage. Ninety-nine MS patients underwent ApoE genotyping, clinical examination, and magnetic resonance imaging at baseline and after 2.7 +/- 1.1 years to assess lesion load (LL) and BVC. In APOE-epsilon4 patients, the annual reduction in brain volume was fivefold higher (-0.65 +/- 0.61%) than in those without APOE-epsilon4 (-0.13 +/- 0.36%; p = 0.0001). At baseline, T(2) LL and T(1) LL were non-significantly higher in epsilon4 carriers, despite a shorter disease duration and absence of significant clinical differences. During follow-up, T(1) LL increased from 1.2 +/- 2.3 ccm to 1.7 +/- 2.7 ccm in the epsilon4 group, although T(2) LL did not change, leading to a significantly higher increase in the BH ratio [(T(1) LL/T(2) LL) x 100] from 5.5 to 12.4% (p = 0.005). BH ratio remained almost constant in non-epsilon4 patients (5.0 vs 5.7%). Accelerated brain tissue loss and a higher proportion of lesions evolving into BH therefore provide magnetic resonance imaging evidence for more pronounced tissue destruction in MS patients with APOE-epsilon4.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Analysis of Variance -
Apolipoprotein E4 -
Apolipoproteins E - genetics
Atrophy - genetics
Brain - pathology
Female - pathology
Follow-Up Studies - pathology
Genotype - pathology
Humans - pathology
Magnetic Resonance Imaging - methods
Male - methods
Middle Aged - methods
Multiple Sclerosis - genetics
Multivariate Analysis - genetics
Statistics, Nonparametric - genetics

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