Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Burwick, RM; Ramsay, PP; Haines, JL; Hauser, SL; Oksenberg, JR; Pericak-Vance, MA; Schmidt, S; Compston, A; Sawcer, S; Cittadella, R; Savettieri, G; Quattrone, A; Polman, CH; Uitdehaag, BM; Zwemmer, JN; Hawkins, CP; Ollier, WE; Weatherby, S; Enzinger, C; Fazekas, F; Schmidt, H; Schmidt, R; Hillert, J; Masterman, T; Hogh, P; Niino, M; Kikuchi, S; Maciel, P; Santos, M; Rio, ME; Kwiecinski, H; Zakrzewska-Pniewska, B; Evangelou, N; Palace, J; Barcellos, LF.
APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers.
NEUROLOGY. 2006; 66(9): 1373-1383.
Web of Science PubMed FullText FullText_MUG Google Scholar


Autor/innen der Med Uni Graz:
Enzinger Christian
Fazekas Franz
Schmidt Helena
Schmidt Reinhold

Dimensions Citations:

Plum Analytics:
BACKGROUND: Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and families genotyped for the APOE epsilon polymorphism. METHODS: Studies of MS and APOE were identified by searches of PubMed, Biosis, Web of Science, Cochrane Review, and Embase. When possible, authors were contacted for individual genotype data. Meta-analyses of MS case-control data and family-based analyses were performed to assess the association of APOE epsilon genotype with disease risk. Pooled analyses of MS cases were also performed to assess the influence of APOE epsilon genotype on disease severity. RESULTS: A total of 22 studies (3,299 MS cases and 2,532 controls) were available for meta-analysis. No effect of epsilon2 or epsilon4 status on MS risk was observed (summary OR 1.14, 95% CI 0.96-1.34 and OR 0.89, 95% CI 0.78-1.01). Results obtained from analyses of APOE genotypes in 1,279 MS families were also negative (p = 0.61). Finally, results from pooled analyses of 4,048 MS cases also argue strongly that APOE epsilon status does not distinguish a relapsing-remitting from primary progressive disease course, or influence disease severity, as measured by the Expanded Disability Status Scale and disease duration. CONCLUSION: Overall, these findings do not support a role for APOE in multiple sclerosis, and underscore the importance of using large sample sizes to detect modest genetic effects, particularly in studies of genotype-phenotype relationships.
Find related publications in this database (using NLM MeSH Indexing)
Alleles -
Apolipoprotein E2 -
Apolipoprotein E4 -
Apolipoproteins E - genetics
Case-Control Studies - genetics
Genetic Predisposition to Disease - genetics
Genotype - genetics
Humans - genetics
Linkage Disequilibrium - genetics
Multiple Sclerosis - epidemiology
Pedigree - epidemiology
Phenotype - epidemiology
Polymorphism, Genetic - epidemiology
Polymorphism, Single Nucleotide - epidemiology
Risk - epidemiology
Severity of Illness Index - epidemiology

© Med Uni Graz Impressum