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SHR Neuro Krebs Kardio Lipid

Peskar, BM; Ehrlich, K; Egger, T; Sattler, W.
Dexamethasone impairs the gastric mucosal integrity in rats treated with a cyclooxygenase-1 but not with a cyclooxygenase-2 inhibitor.
Pharmacology. 2006; 76(4):180-184
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Autor/innen der Med Uni Graz:
Sattler Wolfgang
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Abstract:
In rats, neither the cyclooxygenase-1 inhibitor SC-560 nor the cyclooxygenase-2 inhibitor rofecoxib damages the gastric mucosa. Coadministration of dexamethasone induced injury in SC-560- but not in rofecoxib-treated rats. High levels of cyclooxygenase-1 protein occurred in the gastric mucosa of control rats, with no change after administration of SC-560. In contrast, the gastric cyclooxygenase-2 protein levels were low in control rats, but increased in a time-dependent manner after administration of SC-560. Dexamethasone prevented the increase in cyclooxygenase-2 protein levels. Our findings show that inhibition of cyclooxygenase-1 upregulates cyclooxygenase-2. When the upregulation is prevented by dexamethasone, gastric damage develops, suggesting that induction of cyclooxygenase-2 represents a compensatory mechanism that counteracts the injurious effect of cyclooxygenase-1 inhibition.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Anti-Inflammatory Agents - adverse effects
Cyclooxygenase 1 - biosynthesis
Cyclooxygenase 2 - biosynthesis
Cyclooxygenase 2 Inhibitors - adverse effects
Cyclooxygenase Inhibitors - adverse effects
Dexamethasone - adverse effects
Drug Interactions - adverse effects
Drug Therapy, Combination - adverse effects
Gastric Mucosa - drug effects
Lactones - adverse effects
Male - adverse effects
Pyrazoles - adverse effects
Rats - adverse effects
Rats, Wistar - adverse effects
Sulfones - adverse effects
Time Factors - adverse effects

Find related publications in this database (Keywords)
dexamethasone
cyclooxygenase-1
cyclooxygenase-2
gastric mucosal damage
SC-560
rofecoxib
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