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SHR Neuro Krebs Kardio Lipid

Lakio, L; Lehto, M; Tuomainen, AM; Jauhiainen, M; Malle, E; Asikainen, S; Pussinen, PJ.
Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans.
J ENDOTOXIN RES. 2006; 12(1): 57-64.
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Autor/innen der Med Uni Graz:
Malle Ernst
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Abstract:
An association between cardiovascular and periodontal disease may be due to lipopolysaccharide (LPS)-promoted release of inflammatory mediators, adverse alterations of the lipoprotein profile, and an imbalance in cholesterol homeostasis. Since periodontopathogenic potential differs between serotypes of a major periodontal pathogen, Actinobacillus actinomycetemcomitans, we studied the pro-atherogenic properties of LPS preparations from serotypes b and d strains on macrophages (RAW 264.7). A. actinomycetemcomitans LPS preparations induced a time-dependent release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). LPS induced foam cell formation and cholesteryl ester accumulation from native low density lipoprotein in the following order: A. actinomycetemcomitans strains JP2 (serotype b) > Y4 (serotype b) > IDH781 (serotype d). mRNA expression levels of scavenger receptor class B, type-I, and ATP-binding cassette transporter-1, receptors mediating cholesterol efflux from macrophages, were decreased by LPS preparations. The results suggest that the pro-atherogenic potential of A. actinomycetemcomitans LPS may depend on the infecting strain and correlate with the periodontopathogenic potential of the pathogen.
Find related publications in this database (using NLM MeSH Indexing)
ATP-Binding Cassette Transporters - metabolism
Actinobacillus actinomycetemcomitans - chemistry
Animals - chemistry
Atherosclerosis - chemically induced
Cell Line - chemically induced
Cholesterol, HDL - metabolism
Cholesterol, LDL - metabolism
Cytokines - biosynthesis
Foam Cells - drug effects
Lipid Metabolism - drug effects
Lipopolysaccharides - chemistry
Macrophages - drug effects
Mice - drug effects
Periodontal Diseases - microbiology
RNA - biosynthesis
Reverse Transcriptase Polymerase Chain Reaction - biosynthesis
Scavenger Receptors, Class B - biosynthesis

Find related publications in this database (Keywords)
foam cell formation
infection
inflammation
periodontitis
RAW 264.7 macrophages
SR-BI
ABCA-1
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