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SHR Neuro Krebs Kardio Lipid

Kovacevic, A; Hammer, A; Sundl, M; Pfister, B; Hrzenjak, A; Ray, A; Ray, BK; Sattler, W; Malle, E.
Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells.
FEBS LETT. 2006; 580(1): 161-167. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Hammer Astrid
Hrzenjak Andelko
Malle Ernst
Sattler Wolfgang
Sundl Monika
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Abstract:
The placenta comprises a highly specialized trophoblast layer, which arises from the embryo and differentiates during embryonic development to perform specialized functions, e.g., synthesis of pregnancy-associated hormones, growth factors and cytokines. As there is no evidence of maternal acute-phase protein transplacental transfer and trophoblast plays an important role in regulating immune responses at the feto-maternal interface, the expression of acute-phase serum amyloid A (A-SAA) was investigated in human first trimester trophoblast and trophoblast-like JAR and Jeg-3 choriocarcinoma cells. We here show expression of cytokine receptors and cytokine-dependent induction of A-SAA in JAR and Jeg-3 cells. While interleukin-1alpha/beta is a major agonist for A-SAA expression in JAR, tumor necrosis factor-alpha is the predominant agonist in Jeg-3. First trimester trophoblast and JAR/Jeg-3 cells further express the human homolog of SAA-activating factor-1, a transcription factor involved in cytokine-mediated induction of A-SAA genes. A-SAA1 and A-SAA2 transcripts were increased in first trimester trophoblast during pregnancy weeks 10 and 12 suggesting that A-SAA plays a role during early fetal development.
Find related publications in this database (using NLM MeSH Indexing)
Cell Line, Tumor -
Choriocarcinoma - immunology
Female - immunology
Fetal Development - immunology
Gene Expression Regulation - drug effects
Humans - drug effects
Maternal-Fetal Exchange - immunology
Pregnancy - immunology
Serum Amyloid A Protein - biosynthesis
Trophoblasts - cytology
Tumor Necrosis Factor-alpha - immunology

Find related publications in this database (Keywords)
acute-phase SAA
apolipoprotein
cytokine
inflammation
fetal development
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