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SHR Neuro Krebs Kardio Lipid

Madreiter-Sokolowski, CT; Ramadani-Muja, J; Ziomek, G; Burgstaller, S; Bischof, H; Koshenov, Z; Gottschalk, B; Malli, R; Graier, WF.
Tracking intra- and inter-organelle signaling of mitochondria.
FEBS J. 2019; 286(22):4378-4401 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Bischof Helmut
Burgstaller Sandra
Gottschalk Benjamin
Graier Wolfgang
Koshenov Zhanat
Madreiter-Sokolowski Corina
Malli Roland
Ramadani-Muja Jeta
Ziomek Gabriela

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Number of Figures: 1
Mitochondria are as highly specialized organelles and masters of the cellular energy metabolism in a constant and dynamic interplay with their cellular environment, providing adenosine triphosphate, buffering Ca2+ and fundamentally contributing to various signaling pathways. Hence, such broad field of action within eukaryotic cells requires a high level of structural and functional adaptation. Therefore, mitochondria are constantly moving and undergoing fusion and fission processes, changing their shape and their interaction with other organelles. Moreover, mitochondrial activity gets fine-tuned by intra- and interorganelle H+ , K+ , Na+ , and Ca2+ signaling. In this review, we provide an up-to-date overview on mitochondrial strategies to adapt and respond to, as well as affect, their cellular environment. We also present cutting-edge technologies used to track and investigate subcellular signaling, essential to the understanding of various physiological and pathophysiological processes. © 2019 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

Find related publications in this database (Keywords)
intracellular signaling
mitochondria-associated ER membranes
mitochondrial membrane potential
mitochondrial structure
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