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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Gottschalk, B; Klec, C; Leitinger, G; Bernhart, E; Rost, R; Bischof, H; Madreiter-Sokolowski, CT; Radulović, S; Eroglu, E; Sattler, W; Waldeck-Weiermair, M; Malli, R; Graier, WF.
MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex.
Nat Commun. 2019; 10(1):3732-3732 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Bernhart Eva Maria
Bischof Helmut
Eroglu Emrah
Gottschalk Benjamin
Graier Wolfgang
Klec Christiane
Leitinger Gerd
Madreiter-Sokolowski Corina
Malli Roland
Radulovic Snjezana
Rost René
Sattler Wolfgang
Waldeck-Weiermair Markus

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Number of Figures: 8
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Recently identified core proteins (MICU1, MCU, EMRE) forming the mitochondrial Ca2+ uniporter complex propelled investigations into its physiological workings. Here, we apply structured illumination microscopy to visualize and localize these proteins in living cells. Our data show that MICU1 localizes at the inner boundary membrane (IBM) due to electrostatic interaction of its polybasic domain. Moreover, this exclusive localization of MICU1 is important for the stability of cristae junctions (CJ), cytochrome c release and mitochondrial membrane potential. In contrast to MICU1, MCU and EMRE are homogeneously distributed at the inner mitochondrial membrane under resting conditions. However, upon Ca2+ elevation MCU and EMRE dynamically accumulate at the IBM in a MICU1-dependent manner. Eventually, our findings unveil an essential function of MICU1 in CJ stabilization and provide mechanistic insights of how sophistically MICU1 controls the MCU-Complex while maintaining the structural mitochondrial membrane framework.
Find related publications in this database (using NLM MeSH Indexing)
Calcium - metabolism
Calcium Channels - metabolism
Calcium Signaling - physiology
Calcium-Binding Proteins - metabolism
Cation Transport Proteins - metabolism
Cell Line, Tumor -
HEK293 Cells -
HeLa Cells -
Humans -
MCF-7 Cells -
Membrane Potential, Mitochondrial - physiology
Mitochondrial Membrane Transport Proteins - metabolism
Mitochondrial Membranes - metabolism

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