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SHR Neuro Krebs Kardio Lipid

Degoricija, V; Potočnjak, I; Gastrager, M; Pregartner, G; Berghold, A; Scharnagl, H; Stojakovic, T; Tiran, B; Marsche, G; Frank, S.
HDL subclasses and mortality in acute heart failure patients.
Clin Chim Acta. 2019; 490(2):81-87 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Berghold Andrea
Frank Saša
Marsche Gunther
Pregartner Gudrun
Scharnagl Hubert
Stojakovic Tatjana
Tiran Beate

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The link between HDL subclasses and the prognosis of cardiovascular diseases remains controversial. We thus evaluated the prognostic value of the HDL subclasses 3 and 2 cholesterol (HDL3-C, HDL2-C) as well as of total HDL-C for 3-month mortality in acute heart failure (AHF) patients. The serum levels of HDL3-C and total HDL-C were determined by detergent-based homogeneous assay. HDL2-C was computed by the difference between total HDL-C and HDL3-C. Out of the 132 analyzed patients, 35 (26.5%) died within three months after onset of AHF. Univariate logistic regression analyses revealed a significant inverse association of HDL3-C (odds ratio (OR) 0.46 per 1-SD increase, 95% confidence interval (CI) 0.27-0.72, p = 0.001) with 3-month mortality, whereas concentrations of total HDL-C and HDL2-C showed no significant association. After adjustment for various laboratory and clinical parameters known to be associated with mortality in heart failure patients, HDL3-C concentrations remained significantly associated with 3-month mortality (OR 0.34 per 1-SD increase, 95% CI 0.15-0.74, p =0.010). We conclude that low admission serum levels of HDL3-C are associated with an increased 3-month mortality in AHF patients, whereas total HDL-C and HDL2-C showed no association. HDL3-C might thus be useful as a prognostic parameter in AHF. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Find related publications in this database (Keywords)
HDL3 cholesterol
HDL particles
Homogeneous assays
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