Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Aringer, I; Artinger, K; Kirsch, AH; Schabhüttl, C; Jandl, K; Bärnthaler, T; Mooslechner, A; Herzog, SA; Uhlig, M; Kirsch, A; Frank, S; Banas, M; Pollheimer, M; Eller, P; Rosenkranz, AR; Heinemann, A; Eller, K.
Blockade of Prostaglandin E2 Receptor 4 Ameliorates Nephrotoxic Serum Nephritis.
Am J Physiol Renal Physiol. 2018;
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Aringer Ida
Artinger Katharina
Bärnthaler Thomas
Eller Kathrin
Eller Philipp
Frank Saša
Heinemann Akos
Herzog Sereina Annik
Jandl Katharina
Kirsch Alexander
Kirsch Andrijana
Mooslechner Agnes Anna
Pollheimer Marion
Rosenkranz Alexander
Schabhüttl Corinna

Dimensions Citations:

Plum Analytics:
Prostaglandin E2 (PGE2) signaling is known to modulate inflammation and vascular resistance. Receptors of PGE2 (E-type prostanoid receptors, EP) might be an attractive pharmacological target in immune-mediated diseases such as glomerulonephritis. We hypothesized that selective EP4 antagonism improves nephrotoxic serum nephritis (NTS) by its anti-inflammatory properties. Mice were subjected to NTS and treated with the EP4 antagonist ONO AE3-208 [10 mg/kg bw/day] or vehicle starting from disease initiation. In one set of experiments treatment was started 4 days after NTS induction. Tubular epithelial cells were evaluated in vitro under starving conditions. EP4 antagonist treatment significantly improved the NTS phenotype without affecting blood pressure levels. Remarkably, the improved NTS phenotype was also observed when treatment was started 4 days after NTS induction. EP4 antagonism decreased tubular chemokine (C-x-c motif) ligand -1 ( Cxcl-1) and -5 ( Cxcl-5) expression and thereby subsequently reduced interstitial neutrophil infiltration into the kidney. In vitro, tubular epithelial cells increasingly express Cxcl5 mRNA and Cxcl5 protein when treated with PGE2 or an EP4 agonist under starving conditions, which is blunted by EP4 antagonist treatment. Together, EP4 antagonism improves the NTS phenotype probably by decreasing mainly Cxcl-5 production in tubular cells thereby reducing renal neutrophil infiltration.

Find related publications in this database (Keywords)
immune cells
tubular cells
© Meduni Graz Impressum