Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Knot, HJ; Laher, I; Sobie, EA; Guatimosim, S; Gomez-Viquez, L; Hartmann, H; Song, LS; Lederer, WJ; Graier, WF; Malli, R; Frieden, M; Petersen, OH.
Twenty years of calcium imaging: cell physiology to dye for.
MOL INTERV. 2005; 5(2): 112-127. [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Graier Wolfgang
Malli Roland

Dimensions Citations:

Plum Analytics:
Number of Figures: 9
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The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca(2+) in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca(2+) signaling is accomplished. In excitable cells, the coordination of changing Ca(2+) concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca(2+) signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Calcium - metabolism
Calcium Signaling - metabolism
Cell Physiology - metabolism
Endoplasmic Reticulum - metabolism
Endothelial Cells - cytology
Epithelial Cells - metabolism
Fluorescent Dyes - pharmacology
Humans - pharmacology
Models, Biological - pharmacology
Muscle, Smooth, Vascular - cytology
Rats - cytology
Sarcoplasmic Reticulum - metabolism
Signal Transduction - metabolism
Time Factors - metabolism

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