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SHR Neuro Krebs Kardio Lipid

Zardoya-Laguardia, P; Blaschitz, A; Hirschmugl, B; Lang, I; Herzog, SA; Nikitina, L; Gauster, M; Häusler, M; Cervar-Zivkovic, M; Karpf, E; Maghzal, GJ; Stanley, CP; Stocker, R; Wadsack, C; Frank, S; Sedlmayr, P.
Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.
Sci Rep. 2018; 8(1): 5488-5488. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Blaschitz Astrid
Cervar-Zivkovic Mila
Frank Saša
Gauster Martin
Haeusler Martin
Herzog Sereina Annik
Hirschmugl Birgit
Kampelmühler Eva
Lang-Olip Ingrid
Nikitina Liudmila Aleksandrowna
Sedlmayr Peter
Wadsack Christian
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Abstract:
Indoleamine 2,3-dioxygenase-1 (IDO1) mediates the degradation of L-tryptophan (L-Trp) and is constitutively expressed in the chorionic vascular endothelium of the human placenta with highest levels in the microvasculature. Given that endothelial expression of IDO1 has been shown to regulate vascular tone and blood pressure in mice under the condition of systemic inflammation, we asked whether IDO1 is also involved in the regulation of placental blood flow and if yes, whether this function is potentially impaired in intrauterine growth restriction (IUGR) and pre-eclampsia (PE). In the large arteries of the chorionic plate L-Trp induced relaxation only after upregulation of IDO1 using interferon gamma and tumor necrosis factor alpha. However, ex vivo placental perfusion of pre-constricted cotyledonic vasculature with L-Trp decreases the vessel back pressure without prior IDO1 induction. Further to this finding, IDO1 protein expression and activity is reduced in IUGR and PE when compared to gestational age-matched control tissue. These data suggest that L-Trp catabolism plays a role in the regulation of placental vascular tone, a finding which is potentially linked to placental and fetal growth. In this context our data suggest that IDO1 deficiency is related to the pathogenesis of IUGR and PE.

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