Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Joshi, PK; Pirastu, N; Kentistou, KA; Fischer, K; Hofer, E; Schraut, KE; Clark, DW; Nutile, T; Barnes, CLK; Timmers, PRHJ; Shen, X; Gandin, I; McDaid, AF; Hansen, TF; Gordon, SD; Giulianini, F; Boutin, TS; Abdellaoui, A; Zhao, W; Medina-Gomez, C; Bartz, TM; Trompet, S; Lange, LA; Raffield, L; van der Spek, A; Galesloot, TE; Proitsi, P; Yanek, LR; Bielak, LF; Payton, A; Murgia, F; Concas, MP; Biino, G; Tajuddin, SM; Seppälä, I; Amin, N; Boerwinkle, E; Børglum, AD; Campbell, A; Demerath, EW; Demuth, I; Faul, JD; Ford, I; Gialluisi, A; Gögele, M; Graff, M; Hingorani, A; Hottenga, JJ; Hougaard, DM; Hurme, MA; Ikram, MA; Jylhä, M; Kuh, D; Ligthart, L; Lill, CM; Lindenberger, U; Lumley, T; Mägi, R; Marques-Vidal, P; Medland, SE; Milani, L; Nagy, R; Ollier, WER; Peyser, PA; Pramstaller, PP; Ridker, PM; Rivadeneira, F; Ruggiero, D; Saba, Y; Schmidt, R; Schmidt, H; Slagboom, PE; Smith, BH; Smith, JA; Sotoodehnia, N; Steinhagen-Thiessen, E; van Rooij, FJA; Verbeek, AL; Vermeulen, SH; Vollenweider, P; Wang, Y; Werge, T; Whitfield, JB; Zonderman, AB; Lehtimäki, T; Evans, MK; Pirastu, M; Fuchsberger, C; Bertram, L; Pendleton, N; Kardia, SLR; Ciullo, M; Becker, DM; Wong, A; Psaty, BM; van Duijn, CM; Wilson, JG; Jukema, JW; Kiemeney, L; Uitterlinden, AG; Franceschini, N; North, KE; Weir, DR; Metspalu, A; Boomsma, DI; Hayward, C; Chasman, D; Martin, NG; Sattar, N; Campbell, H; Esko, T; Kutalik, Z; Wilson, JF.
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
Nat Commun. 2017; 8(1):910-910 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Hofer Edith
Saba Yasaman
Schmidt Helena
Schmidt Reinhold
Gendermonitor:
Altmetrics:

Dimensions Citations:
Number of Figures: 5
| | | | |
Abstract:
Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated. We suggest that the effect of education on lifespan is principally mediated through smoking while the effect of obesity appears to act via CAD. Using instrumental variables, we suggest that an increase of one body mass index unit reduces lifespan by 7 months while 1 year of education adds 11 months to expected lifespan.Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.

© Meduni Graz Impressum